Curcumin activates defensive genes and protects neurons against oxidative stress. (Articolo in rivista)

Type
Label
  • Curcumin activates defensive genes and protects neurons against oxidative stress. (Articolo in rivista) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Alternative label
  • Scapagnini G, Colombrita C, Amadio M, D'Agata V, Arcelli E, Sapienza M, Quattrone A, Calabrese V. (2006)
    Curcumin activates defensive genes and protects neurons against oxidative stress.
    in Antioxidants & redox signalling
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Scapagnini G, Colombrita C, Amadio M, D'Agata V, Arcelli E, Sapienza M, Quattrone A, Calabrese V. (literal)
Pagina inizio
  • 395 (literal)
Pagina fine
  • 403 (literal)
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  • 8(3-4 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
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  • Institute of Neurological Sciences, National Research Council (CNR), Catania, Italy. (literal)
Titolo
  • Curcumin activates defensive genes and protects neurons against oxidative stress. (literal)
Abstract
  • Spices and herbs often contain active phenolic substances endowed with potent antioxidative properties. We had previously shown that curcumin, the yellow pigment in curry, strongly induced HO-1 expression and activity in rat astrocytes. In the CNS, HO-1 has been reported to operate as a fundamental defensive mechanism for neurons exposed to an oxidant challenge. Treatment of astrocytes with curcumin upregulated expression of HO-1 protein at both cytoplasmic and nuclear levels, as shown by immunofluorescence analysis under laser-scanning confocal microscopy. A significant expression of quinone reductase and glutathione S transferase, two members of phase II detoxification enzymes, was found in astrocytes exposed to 5-15 microM curcumin. Moreover, the effects of curcumin on HO-1 activity were explored in cultured hippocampal neurons. Elevated expression of HO-1 mRNA and protein were detected after 6 h incubation with 5-25 microM curcumin. Higher concentrations of curcumin (50-100 microM) caused a substantial cytotoxic effect with no change in HO-1 protein expression. Interestingly, pre-incubation (18 h) with curcumin resulted in an enhanced cellular resistance to glucose oxidase-mediated oxidative damage; this cytoprotective effect was considerably attenuated by zinc protoporphyrin IX, an inhibitor of heme oxygenase activity. This study gives additional support to the possible use of curcumin as a dietary preventive agent against oxidative stress-related diseases (literal)
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