Levetiracetam in patients with generalised epilepsy and myoclonic seizures: an open label study (Articolo in rivista)

Type
Label
  • Levetiracetam in patients with generalised epilepsy and myoclonic seizures: an open label study (Articolo in rivista) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Alternative label
  • Labate A, Colosimo E, Gambardella A, Leggio U, Ambrosio R, Quattrone A. (2006)
    Levetiracetam in patients with generalised epilepsy and myoclonic seizures: an open label study
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Labate A, Colosimo E, Gambardella A, Leggio U, Ambrosio R, Quattrone A. (literal)
Pagina inizio
  • 214 (literal)
Pagina fine
  • 218 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 15 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Titolo
  • Levetiracetam in patients with generalised epilepsy and myoclonic seizures: an open label study (literal)
Abstract
  • PURPOSE: To evaluate the efficacy and tolerability of levetiracetam (LEV) as either 'de novo' (monotherapy) or 'add-on' therapy in patients with different generalised epilepsies characterised by myoclonic seizures from an observational study. METHODS: We evaluated 35 patients (21 female, mean age 24.7 years) with different types of generalised epilepsies (juvenile myoclonic epilepsy (JME), severe myoclonic epilepsy of infancy (SMEI), Lennox-Gastaut syndrome (LGS), myoclonic-astatic epilepsy (MAE), myoclonic absences (MA), benign myoclonic epilepsy in infancy (BMEI) and 4 patients had unspecified epileptic syndromes). Patients received LEV as de novo monotherapy or add-on therapy. Seizure frequency changes and adverse events were observed. Follow-up was conducted for a period of 12 months after treatment. RESULTS: Patients received LEV 2000-3000 mg/day as de novo (n = 8) and as add-on therapy. In total, 29 (82%) of the 35 patients achieved > or = 50% seizure frequency reduction, 15 (42%) patients achieved seizure freedom while a further 14 (40%) patients achieved > or = 50-99% seizure frequency reduction. Six (17%) patients discontinued LEV due to inefficacy or seizure worsening. Not even a single patient discontinued due to adverse effects. CONCLUSIONS: Our results confirm that LEV as de novo (monotherapy) and add-on therapy at doses between 2000 and 3000 mg/day effectively reduces myoclonic seizure frequency in patients with generalised epilepsy. LEV was also well-tolerated. (literal)
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