Sex differences in clinical and genetic determinants of levodopa peak-dose dyskinesias in Parkinson disease: an exploratory study. (Articolo in rivista)

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  • Sex differences in clinical and genetic determinants of levodopa peak-dose dyskinesias in Parkinson disease: an exploratory study. (Articolo in rivista) (literal)
Anno
  • 2005-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1001/archneur.62.4.601 (literal)
Alternative label
  • Zappia M; Annesi G; Nicoletti G; Arabia G, Annesi F; Messina D; Pugliese P; Spadafora P; Tarantino P; Carrideo S; Civitelli D; De Marco EV; Ciro-Candiano IC; Gambardella A; Quattrone A. (2005)
    Sex differences in clinical and genetic determinants of levodopa peak-dose dyskinesias in Parkinson disease: an exploratory study.
    in Archives of neurology (Chic.)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Zappia M; Annesi G; Nicoletti G; Arabia G, Annesi F; Messina D; Pugliese P; Spadafora P; Tarantino P; Carrideo S; Civitelli D; De Marco EV; Ciro-Candiano IC; Gambardella A; Quattrone A. (literal)
Pagina inizio
  • 601 (literal)
Pagina fine
  • 605 (literal)
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  • 62 (literal)
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  • ISI Web of Science (WOS) (literal)
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  • Zappia M: Institute of Neurology, University \"Magna Græcia,\" Catanzaro, Italy - Institute of Neurological Sciences, National Research Council, Piano Lago-Cosenza, Italy Annesi G: Institute of Neurological Sciences, National Research Council, Piano Lago-Cosenza, Italy Nicoletti G: Institute of Neurological Sciences, National Research Council, Piano Lago-Cosenza, Italy Arabia G: Institute of Neurology, University \"Magna Græcia,\" Catanzaro, Italy Annesi F: Institute of Neurological Sciences, National Research Council, Piano Lago-Cosenza, Italy Messina D: Institute of Neurological Sciences, National Research Council, Piano Lago-Cosenza, Italy Pugliese P: Institute of Neurology, University \"Magna Græcia,\" Catanzaro, Italy Spadafora P: Institute of Neurological Sciences, National Research Council, Piano Lago-Cosenza, Italy Tarantino P: Institute of Neurological Sciences, National Research Council, Piano Lago-Cosenza, Italy Carrideo S: Institute of Neurological Sciences, National Research Council, Piano Lago-Cosenza, Italy Civitelli D Institute of Neurological Sciences, National Research Council, Piano Lago-Cosenza, Italy De Marco EV Institute of Neurological Sciences, National Research Council, Piano Lago-Cosenza, Italy Cirò-Candiano IC Institute of Neurological Sciences, National Research Council, Piano Lago-Cosenza, Italy Gambardella A: Institute of Neurology, University \"Magna Græcia,\" Catanzaro, Italy Quattrone A: Institute of Neurology, University \"Magna Græcia,\" Catanzaro, Italy - Institute of Neurological Sciences, National Research Council, Piano Lago-Cosenza, Italy (literal)
Titolo
  • Sex differences in clinical and genetic determinants of levodopa peak-dose dyskinesias in Parkinson disease: an exploratory study. (literal)
Abstract
  • BACKGROUND: Several factors, both clinical and genetic, may account for the risk of developing levodopa-induced peak-dose dyskinesias (PDD) in patients with Parkinson disease, but it is unclear how these factors interact for modulating the individual susceptibility for PDD. OBJECTIVE: To examine clinical and genetic risk factors for determining individual susceptibility of PDD in patients with Parkinson disease. DESIGN: Cohort study. SETTING: Referral center for Parkinson disease in Calabria, southern Italy.Patients Two hundred fifty patients with Parkinson disease were screened for the presence or absence of PDD following a short-term levodopa administration, and 215 subjects were available for further evaluations, including genotypic analysis of the CA dinucleotide short tandem repeat (CAn-STR) polymorphism located in the dopamine receptor D2 gene (DRD2). RESULTS: One hundred five patients (48.8%) exhibited PDD following short-term levodopa administration, and 110 patients (51.2%) did not. Multivariate logistic regression analysis showed that independent predictors for the occurrence of PDD were female sex, earlier age at onset of Parkinson disease, longer duration of treatment, and higher dose of levodopa. Genetic factors related to the DRD2 CAn-STR polymorphism were not independent predictors for PDD in the total population, but they had a strong protective effect on the appearance of PDD when the multivariate analysis was performed in men (odds ratio, 0.34 [95% confidence interval, 0.14-0.84]). In women, a genetic protective effect on PDD was not evident. CONCLUSIONS: Risk factors for PDD, both clinical and genetic, act in different ways for men and women. Genetic factors related to the DRD2 polymorphic status have a protective effect on PDD development in men but not in women. A female sex-related effect for the risk of PDD may be so strong that it overcomes any protective effect due to genetic factors. (literal)
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