http://www.cnr.it/ontology/cnr/individuo/prodotto/ID4985

Effects of Acute Perinatal Asphyxia in the Rat Hippocampus (Articolo in rivista)

Type

Label

Effects of Acute Perinatal Asphyxia in the Rat Hippocampus (Articolo in rivista) (literal)

Anno

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

Alternative label

Frizzo J.K. 1, Cardoso M.P. 2, de Assis A.M. 3, Perry M.L. 3, Volonté C. 1,4, Frizzo M.E. 1,2 (2010)
Effects of Acute Perinatal Asphyxia in the Rat Hippocampus
in Cellular and molecular neurobiology
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Frizzo J.K. 1, Cardoso M.P. 2, de Assis A.M. 3, Perry M.L. 3, Volonté C. 1,4, Frizzo M.E. 1,2 (literal)

Pagina inizio

Pagina fine

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

Rivista

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

Note

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

1 - Santa Lucia, Neurobiology Unit, CNR/Fondazione Santa Lucia, 65 Via del Fosso di Fiorano, 00143 Rome, Italy; 2 - Department of Morphological Sciences, UFRGS, Rua Sarmento Leite, 500, CEP 90050-170 Porto Alegre, Brazil; 3 - Department of Biochemistry, UFRGS, Rua Ramiro Barcelos, 2600, CEP 90035-003 Porto Alegre, Brazil; 4 - Institute of Neurobiology and Molecular Medicine, CNR, Via del Fosso di Fiorano 64, Località Prato Smeraldo, 00143 Rome, Italy (literal)

Titolo

Abstract

In the present work, we have used a rat animal model to study the early effects of intrauterine asphyxia occurring no later than 60 min following the cesarean-delivery procedure. Transitory hypertonia accompanied by altered posture was observed in asphyxiated pups, which also showed appreciably increased lactate values in plasma and hippocampal tissues. Despite this, there was no difference in terms of either cell viability or metabolic activities such as oxidation of lactate, glucose, and glycine in the hippocampus of those fetuses submitted to perinatal asphyxia with respect to normoxic animals. Moreover, a significant decrease in glutamate, but not GABA uptake was observed in the hippocampus of asphyctic pups. Since intense ATP signaling especially through P2X(7) purinergic receptors can lead to excitotoxicity, a feature which initiates neurotransmission failure in experimental paradigms relevant to ischemia, here we assessed the expression level of the P2X(7) receptor in the paradigm of perinatal asphyxia. A three-fold increase in P2X(7) protein was transiently observed in hippocampus immediately following asphyxia. Nevertheless, further studies are needed to delineate whether the P2X(7) receptor subtype is involved in the pathogenesis, contributing to ongoing brain injury after intrapartum asphyxia. In that case, new pharmacologic intervention strategies providing neuroprotection during the reperfusion phase of injury might be identified. (literal)

Prodotto di