The telomerase tale in vascular aging: Regulation by estrogens and nitric oxide signaling (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• The telomerase tale in vascular aging: Regulation by estrogens and nitric oxide signaling (Articolo in rivista) (literal)

Anno

• 2009-01-01T00:00:00+01:00 (literal)

Alternative label

• Farsetti A. 1; Grasselli A. 1; Bacchetti S. 1; Gaetano C. 2; Capogrossi M.C. 2 (2009)
  The telomerase tale in vascular aging: Regulation by estrogens and nitric oxide signaling
  in Journal of applied physiology (1985)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Farsetti A. 1; Grasselli A. 1; Bacchetti S. 1; Gaetano C. 2; Capogrossi M.C. 2 (literal)

Pagina inizio

• 333 (literal)

Pagina fine

• 337 (literal)

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• 106 (literal)

Rivista

• Journal of applied physiology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• E-pub ahead of print November 20, 2008 {doi:10.1152/japplphysiol.91360} (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1 - Department of Experimental Oncology, Molecular Oncogenesis Laboratory, Experimental Research Center, Regina Elena Institute and Institute of Neurobiology and Molecular Medicine, National Research Council, Rome, Italy; 2 - Laboratorio di Patologia Vascolare, Istituto Dermopatico dell'Immacolata-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy (literal)

Titolo

• The telomerase tale in vascular aging: Regulation by estrogens and nitric oxide signaling (literal)

Abstract

• Hormones and nitric oxide (NO), a free radical, are ancestral molecules, conserved through evolution, that modulate many aspects of the physiology and pathophysiology of living organisms by regulating transcription of genes involved in development, metabolism, and differentiation. Of interest, both estrogen and NO signaling, specifically through the estrogen receptor-{alpha} (ER{alpha}) and the endothelial isoform of the nitric oxide synthase (eNOS), have been shown to counteract endothelial senescence through a shared downstream effector, the catalytic subunit of human telomerase (hTERT), a key molecule in the aging process. Since aging is the first and most relevant risk factor in cardiovascular diseases, it is tempting to speculate that hTERT may be at the cross point between the NO and estrogen pathways. The present review will focus on the evolutionary and molecular aspects linking eNOS, ERs, and hTERT in counteracting the process of endothelial cell aging. (literal)

Prodotto di

• Meccanismi regolativi del Differenziamento e Oncogenesi (ME.P03.007.001) (Modulo)
• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)

Autore CNR

• ANNALISA GRASSELLI (Persona)
• ANTONELLA FARSETTI (Persona)

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• Parole chiave di "The telomerase tale in vascular aging: Regulation by estrogens and nitric oxide signaling" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• ANTONELLA FARSETTI (Persona)
• ANNALISA GRASSELLI (Persona)

Prodotto

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)
• Meccanismi regolativi del Differenziamento e Oncogenesi (ME.P03.007.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of applied physiology (Rivista)

Insieme di parole chiave di

• Parole chiave di "The telomerase tale in vascular aging: Regulation by estrogens and nitric oxide signaling" (Insieme di parole chiave)