The isopeptidase USP2a protects human prostate cancer from apoptosis (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• The isopeptidase USP2a protects human prostate cancer from apoptosis (Articolo in rivista) (literal)

Anno

• 2006-01-01T00:00:00+01:00 (literal)

Alternative label

• Carmen Priolo,1,5,7 Dan Tang,1 Mohan Brahamandan,1 Barbara Benassi,1,5 Ewa Sicinska,1 Shuji Ogino,1,2 Antonella Farsetti,5,6 Alessandro Porrello,4,5 Stephen Finn,1 Johann Zimmermann,3 Phillip Febbo,4 and Massimo Loda1,2 (2006)
  The isopeptidase USP2a protects human prostate cancer from apoptosis
  in Cancer research (Chic. Ill.)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Carmen Priolo,1,5,7 Dan Tang,1 Mohan Brahamandan,1 Barbara Benassi,1,5 Ewa Sicinska,1 Shuji Ogino,1,2 Antonella Farsetti,5,6 Alessandro Porrello,4,5 Stephen Finn,1 Johann Zimmermann,3 Phillip Febbo,4 and Massimo Loda1,2 (literal)

Pagina inizio

• 8625 (literal)

Pagina fine

• 8632 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 66 (literal)

Rivista

• Cancer research (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• Fasc. 17 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1Medical Oncology, Dana-Farber Cancer Institute and 2Pathology Department, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; 3Novartis Pharma, Oncology Research, Basel, Switzerland; 4Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina; and 5Departments of Medical Oncology and Experimental Oncology, Regina Elena Cancer Institute, 6INeMM, National Research Council and 7Endocrinology, Catholic University, Rome, Italy (literal)

Titolo

• The isopeptidase USP2a protects human prostate cancer from apoptosis (literal)

Abstract

• Deubiquitinating enzymes can prevent the destruction of protein substrates prior to proteasomal degradation. The ubiquitin-specific protease 2a (USP2a)deubiquitinat es the antiapoptotic proteins Fatty Acid Synthase and Mdm2. Here, we show that when USP2a is overexpressed in nontransformed cells, it exhibits oncogenic behavior both in vitro and in vivo and prevents apoptosis induced by chemotherapeutic agents. Notably, USP2a silencing in several human cancer cell lines results in apoptosis. Gene set enrichment analysis, which focuses on groups of genes sharing biological function or regulatory pathways, was done on microarray expression data from human prostate cancers. The cell death-related gene set, as well as a selected cluster of validated p53 target genes, were significantly enriched in the low USP2a expression group of tumors. Conversely, genes implicated in fatty acid metabolism were significantly associated with tumors expressing high USP2a (44%). The expression profile analysis is consistent with the effects of USP2a on its known targets, i.e., Fatty Acid Synthase and Mdm2, defining a subset of prostate tumors resistant to apoptosis. USP2a thus represents a therapeutic target in prostate cancer. (literal)

Prodotto di

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)
• Meccanismi regolativi del Differenziamento e Oncogenesi (ME.P03.007.001) (Modulo)

Autore CNR

• ANTONELLA FARSETTI (Unità di personale interno)

Incoming links:

Autore CNR di

• ANTONELLA FARSETTI (Unità di personale interno)

Prodotto

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)
• Meccanismi regolativi del Differenziamento e Oncogenesi (ME.P03.007.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Cancer research (Rivista)