A Straightforward Synthesis of Enantiopure 2,6-Disubstituted Morpholines by Regioselective O-Protection/Activation Protocol (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• A Straightforward Synthesis of Enantiopure 2,6-Disubstituted Morpholines by Regioselective O-Protection/Activation Protocol (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1055/s-2008-1078054 (literal)

Alternative label

• Penso, M.; Lupi, V.; Albanese, D.; Foschi, F.; Landini, D.; Tagliabue, A. (2008)
  A Straightforward Synthesis of Enantiopure 2,6-Disubstituted Morpholines by Regioselective O-Protection/Activation Protocol
  in Synlett (Stuttg.)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Penso, M.; Lupi, V.; Albanese, D.; Foschi, F.; Landini, D.; Tagliabue, A. (literal)

Pagina inizio

• 2451 (literal)

Pagina fine

• 2454 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• https://www.thieme-connect.de/DOI/DOI?10.1055/s-2008-1078054 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 16 (literal)

Rivista

• Synlett (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• CNR-ISTM, Milano. Dipartimento di Chimica Organica e Industriale dell’Università degli Studi di Milano. Nerviano Medical Sciences. (literal)

Titolo

• A Straightforward Synthesis of Enantiopure 2,6-Disubstituted Morpholines by Regioselective O-Protection/Activation Protocol (literal)

Abstract

• Enantiopure 2,6-disubstituted morpholines have been synthesized through the ring opening of chiral, nonracemic oxiranes with nitrogen nucleophiles, under solid-liquid phase-transfer catalysis (SL-PTC) conditions. The beta-hydroxytosyl amides resulting from the ring opening of a first epoxide with TsNH2 was used as nucleophile, after protection of the hydroxyl group, in the reaction with a second oxirane. The morpholine skeleton has been generated through standard functional group chemistry, followed by cyclization of the intermediate beta-hydroxy-beta'-tosyloxy-tosylamides carried out under SL-PTC conditions. N-Tosyl morpholines produced can be employed as building blocks in the synthesis of pharmaceuticals and as chiral tools (literal)

Prodotto di

• Istituto di scienze e tecnologie molecolari (ISTM) (Istituto)
• Catalizzatori per la produzione chemo-, regio- e stereoselettiva di fine chemicals (PM.P03.002.002) (Modulo)

Autore CNR

• MICHELE PENSO (Persona)

Insieme di parole chiave

• Keywords of "A Straightforward Synthesis of Enantiopure 2,6-Disubstituted Morpholines by Regioselective O-Protection/Activation Protocol" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di scienze e tecnologie molecolari (ISTM) (Istituto)
• Catalizzatori per la produzione chemo-, regio- e stereoselettiva di fine chemicals (PM.P03.002.002) (Modulo)

Autore CNR di

• MICHELE PENSO (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Synlett (Rivista)

Insieme di parole chiave di

• Keywords of "A Straightforward Synthesis of Enantiopure 2,6-Disubstituted Morpholines by Regioselective O-Protection/Activation Protocol" (Insieme di parole chiave)