The aluminium(III)-sialic acid interaction: A potential role in aluminium-induced cellular membrane degeneration (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• The aluminium(III)-sialic acid interaction: A potential role in aluminium-induced cellular membrane degeneration (Articolo in rivista) (literal)

Anno

• 2006-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.ica.2006.06.030 (literal)

Alternative label

• 1-Di Marco V.B.; 2-Károly-Lakatos A.; 3-Venzo A.; 4-Bertani R.; 5-Seraglia R.; 6-Kiss T. (2006)
  The aluminium(III)-sialic acid interaction: A potential role in aluminium-induced cellular membrane degeneration
  in Inorganica Chimica Acta (Testo stamp.); Elsevier B.V., Amsterdam (Belgio)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• 1-Di Marco V.B.; 2-Károly-Lakatos A.; 3-Venzo A.; 4-Bertani R.; 5-Seraglia R.; 6-Kiss T. (literal)

Pagina inizio

• 4227 (literal)

Pagina fine

• 4234 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.elsevier.com/locate/ica (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 359 (literal)

Rivista

• Inorganica Chimica Acta (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 8 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1-Department of Chemical Sciences, University of Padova, via Marzolo 1, 35131 Padova, Italy 2-Bioinorganic Chemistry Research Group of the Hungarian Academy of Sciences, University of Szeged, P.O. Box 440, H-6701 Szeged, Hungary 3-CNR-ISTM, Institute of Sciences and Molecular Technologies, via Marzolo 1, 35131 Padova, Italy 4-Department of Chemical Processes of Engineering, University of Padova, via Marzolo 9, 35131 Padova, Italy 5-CNR-ISTM, Institute of Sciences and Molecular Technologies, Corso Stati Uniti 4, 35100 Padova, Italy 6-Department of Inorganic and Analytical Chemistry, University of Szeged, P.O. Box 440, H-6701 Szeged, Hungary (literal)

Titolo

• The aluminium(III)-sialic acid interaction: A potential role in aluminium-induced cellular membrane degeneration (literal)

Abstract

• The coordination between Al(III) and sialic acid ( N -acetylneuraminic acid, HL, pKa=2.58±0.01) was studied by potentiometric titrations at 25 °C in aqueous 0.2 M KCl, by 1H NMR, and by electrospray ionization mass spectrometry (ESI-MS). The potentiometric measurements gave the following aluminium complex stoichiometries and stability constants: logß(AlLH-1+)=-1.28±0.01, logß(AlLH-2)= -6.34±0.02, and logß(AlL2H-1)= -1.14±0.04. The 1H NMR spectra yielded structural information on species AlLH-1+. The ESI-MS data confirmed the metal-ligand stoichiometry of the complexes. The metal-ligand speciation at micromolar Al(III) concentrations (i.e., under in vivo conditions) at physiological pH values reveals that considerable amount of Al(III) is complexed. This suggests that the toxic effect of Al(III) towards cellular membranes might be due to its coordination by protein-bound sialic acid. (literal)

Editore

• Elsevier B.V. (Editore)

Prodotto di

• Istituto di scienze e tecnologie molecolari (ISTM) (Istituto)
• Sistemi molecolari e prodotti funzionali (PM.P03.010.001) (Modulo)

Autore CNR

• ALFONSO VENZO (Unità di personale interno)
• ROBERTA SERAGLIA (Persona)

Insieme di parole chiave

• Keywords of "The aluminium(III)-sialic acid interaction: A potential role in aluminium-induced cellular membrane degeneration" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di scienze e tecnologie molecolari (ISTM) (Istituto)
• Sistemi molecolari e prodotti funzionali (PM.P03.010.001) (Modulo)

Autore CNR di

• ROBERTA SERAGLIA (Persona)
• ALFONSO VENZO (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Inorganica Chimica Acta (Rivista)

Editore di

• Elsevier B.V. (Editore)

Insieme di parole chiave di

• Keywords of "The aluminium(III)-sialic acid interaction: A potential role in aluminium-induced cellular membrane degeneration" (Insieme di parole chiave)