Grey matter changes in posterior cingulate and limbic cortex in PTSD are associated with trauma load and EMDR outcome (Articolo in rivista)

Type
Label
  • Grey matter changes in posterior cingulate and limbic cortex in PTSD are associated with trauma load and EMDR outcome (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Alternative label
  • Nardo D; Högberg G; D, Looi J; Larsson SA; Hällström T; Pagani M (2010)
    Grey matter changes in posterior cingulate and limbic cortex in PTSD are associated with trauma load and EMDR outcome
    in Journal of psychiatric research
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Nardo D; Högberg G; D, Looi J; Larsson SA; Hällström T; Pagani M (literal)
Pagina inizio
  • 477 (literal)
Pagina fine
  • 485 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 44 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Neuroimaging Laboratory, Santa Lucia Foundation, Rome, Italy Department of Clinical Neuroscience, Section for Psychiatry, Huddinge, Karolinska Institute, Stockholm, Sweden Research Centre for the Neurosciences of Ageing, Academic Unit of Psychological Medicine, Australian National University Medical School, The Canberra Hospital,Australian Capital Territory, Australia Department of Nuclear Medicine, Karolinska Hospital, Stockholm, Sweden Institute of Sciences and Technologies of Cognition, CNR, Rome, Italy (literal)
Titolo
  • Grey matter changes in posterior cingulate and limbic cortex in PTSD are associated with trauma load and EMDR outcome (literal)
Abstract
  • There is converging evidence of gray matter (GM) structural alterations in different limbic structures in Post-Traumatic Stress Disorder (PTSD) patients. The aim of this study was to evaluate GM density in PTSD in relation to trauma load, and to assess the GM differences between responders (R) and non-responders (NR) to EMDR therapy. Magnetic Resonance Imaging (MRI) scans of 21 subjects exposed to occupational trauma, who developed PTSD (S), and of 22 who did not (NS), were compared by means of an optimized Voxel-Based Morphometry (VBM) analysis as implemented in SPM. Within S, further comparisons were made between 10 R and 5 NR. A regression analysis between GM density and the Traumatic Antecedents Questionnaire (TAQ) was also performed on all 43 subjects. Results showed a significantly lower GM den- sity in S as compared to NS in the left posterior cingulate and the left posterior parahippocampal gyrus. Moreover, NR showed a significantly lower GM density as compared to R in bilateral posterior cingulate, as well as anterior insula, anterior parahippocampal gyrus and amygdala in the right hemisphere. Regres- sion analysis showed that GM density negatively correlated with trauma load in bilateral posterior cin- gulate, left anterior insula, and right anterior parahippocampal gyrus. In conclusion, a GM lower density in limbic and paralimbic cortices were found to be associated with PTSD diagnosis, trauma load, and EMDR treatment outcome, suggesting a view of PTSD characterized by memory and dissociative disturbances. (literal)
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