MCI patients Declining and not-declining at mid-term follow-up: FDG-PET findings (Articolo in rivista)

Type
Label
  • MCI patients Declining and not-declining at mid-term follow-up: FDG-PET findings (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Alternative label
  • Pagani M; Dessi B;Morbelli S;Brugnolo A;Salmaso D Piccini A;Mazzei D;Villavecchia G;Larsson SA;Rodriguez G; Nobili F. (2010)
    MCI patients Declining and not-declining at mid-term follow-up: FDG-PET findings
    in Current Alzheimer research (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Pagani M; Dessi B;Morbelli S;Brugnolo A;Salmaso D Piccini A;Mazzei D;Villavecchia G;Larsson SA;Rodriguez G; Nobili F. (literal)
Pagina inizio
  • 287 (literal)
Pagina fine
  • 294 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 7 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • http://www.bentham.org/car/CurrentIssue.htm (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Institute of Cognitive Sciences and Technologies, CNR, Rome & Padua, Italy; Clinical Neurophysiology and Alzheimer Evaluation Unit, Dept. of Neurosciences, Ophtalmology and Genetics (DiNOG) and Head-Neck Department (DipTeC), University-Hospital S. Martino, Genoa, Italy; Nuclear Medicine Unit, Dept. of Internal Medicine, University of Genoa, Italy Department of Nuclear Medicine, Karolinska Hospital, Stockholm, Sweden 5Cell Biology Unit, National Cancer Research Institute, Genoa, Italy 6Nuclear Medicine Unit, Dept. of Imaging Diagnostics, Galliera Hospital, Genoa, Italy (literal)
Titolo
  • MCI patients Declining and not-declining at mid-term follow-up: FDG-PET findings (literal)
Abstract
  • ABSTRACT Patients with Mild Cognitive Impairment (MCI) not converted to dementia at one to three years follow-up represent a heterogeneous group across studies, by including ‘late converters’ but also patients without any neurodegenerative disease. We tested the hypothesis that the combination of memory and brain metabolic assessment could identify subgroups of memory decliners (MCI/Decl) and non-decliners (MCI/noDecl) before a long follow-up time is available. From twenty-nine patients with amnestic MCI (aMCI) at baseline, three groups were identified at follow-up: 10 patients who converted to AD (MCI/AD); 10 patients either showing episodic memory worsening or reaching the floor effect on memory and declining in other key tests (MCI/Decl) and 9 patients showing no memory worsening or even improvement (MCI/noDecl). They were compared with a group of fourteen elderly controls (CTR) by means of basal FDG-PET voxel-based analysis (SPM2). Two hypometabolic clusters were found in MCI/AD versus CTR, including the bilateral posterior cingulate cortex, the left parietal precuneus and the left fusiform gyrus. MCI/AD showed also a large hypometabolic region, mainly including the left medium and superior temporal gyri and inferior parietal lobule, when compared to MCI/noDecl. The MCI/Decl showed a hypometabolic region in the left medial temporal lobe versus both CTR (hippocampus) and MCI/noDecl (parahippocampal gyrus and hippocampus). No significant difference was found in the comparison between CTR and MCI/noDecl, neither in the comparison between MCI/Decl and MCI/AD. Thus, non converter MCI patients comprised a sub-group of ‘decliners’ with AD-like metabolic and cognitive patterns, likely including ‘late converters’, and a sub-group lacking this pattern, with stable or improving memory function and a brain metabolic picture similar to that in healthy controls. Combining neuropsychological and FDG-PET information could be used for prognostic purposes in aMCI patients at medium-term follow-up. (literal)
Prodotto di
Autore CNR
Insieme di parole chiave

Incoming links:


Autore CNR di
Prodotto
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
Insieme di parole chiave di
data.CNR.it