http://www.cnr.it/ontology/cnr/individuo/prodotto/ID47076

Principal component analysis in mild and moderate Alzheimer\'s disease - A novel approach to clinical diagnosis (Articolo in rivista)

Type

Articolo in rivista (Classe)
Prodotto della ricerca (Classe)

Label

Principal component analysis in mild and moderate Alzheimer\'s disease - A novel approach to clinical diagnosis (Articolo in rivista) (literal)

Anno

2009-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1016/j.pscychresns.2008.07.016 (literal)

Alternative label

Pagani M, Salmaso D, Rodriguez G, Nardo D, Nobili F (2009)
Principal component analysis in mild and moderate Alzheimer\'s disease - A novel approach to clinical diagnosis
in Psychiatry research. Neuroimaging (Print); Elsevier Ireland Ltd., Clare (Irlanda)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Pagani M, Salmaso D, Rodriguez G, Nardo D, Nobili F (literal)

Pagina inizio

8 (literal)

Pagina fine

14 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

173 (literal)

Rivista

Psychiatry research. Neuroimaging (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

http://dx.doi.org/10.1016/j.pscychresns.2008.07.016 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

7 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto

articolo su rivista internazionale (literal)

Note

ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

Institute of Cognitive Sciences and Technologies, CNR, Rome & Padua, Italy Department of Nuclear Medicine, Karolinska Hospital, Stockholm, Sweden Clinical Neurophysiology, Departmentt of Endocrinological and Medical Sciences, S. Martino Hospital and University of Genoa, Italy Department of Neuroscience, AFaR, Ospedale Fatebenefratelli, Rome, Italy (literal)

Titolo

Principal component analysis in mild and moderate Alzheimer\'s disease - A novel approach to clinical diagnosis (literal)

Abstract

Principal component analysis (PCA) provides a method to explore functional brain connectivity. The aim of this study was to identify regional cerebral blood flow (rCBF) distribution differences between Alzheimer's disease (AD) patients and controls (CTR) by means of volume of interest (VOI) analysis and PCA. Thirty-seven CTR, 30 mild AD (mildAD) and 27 moderate AD (modAD) subjects were investigated using single photon emission computed tomography with 99mTc-hexamethylpropylene amine oxime. Analysis of covariance (ANCOVA), PCA, and discriminant analysis (DA) were performed on 54 VOIs. VOI analysis identified in both mildAD and modAD subjects a decreased rCBF in six regions. PCA in mildAD subjects identified four principal components (PCs) in which the correlated VOIs showed a decreased level of rCBF, including regions that are typically affected early in the disease. In five PCs, including parietal-temporal-limbic cortex, and hippocampus, a significantly lower rCBF in correlated VOIs was found in modAD subjects. DA significantly discriminated the groups. The percentage of subjects correctly classified was 95, 70, and 81 for CTR, mildAD and modAD groups, respectively. PCA highlighted, in mildAD and modAD, relationships not evident when brain regions are considered as independent of each other, and it was effective in discriminating groups. These findings may allow neurophysiological inferences to be drawn regarding brain functional connectivity in AD that might not be possible with univariate analysis. (literal)

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