http://www.cnr.it/ontology/cnr/individuo/prodotto/ID46995

Caudate volumes in public transportation workers exposed to trauma in the Stockholm train system (Articolo in rivista)

Type

Prodotto della ricerca (Classe)
Articolo in rivista (Classe)

Label

Caudate volumes in public transportation workers exposed to trauma in the Stockholm train system (Articolo in rivista) (literal)

Anno

2009-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1016/j.pscychresns.2008.03.011 (literal)

Alternative label

Looi JCL, Mallerc JJ, Pagani M, Högberg G, Lindberg O, Liberg B, Botes L, Engman EL, Zhang Y, Svensson L, Wahlund LO (2009)
Caudate volumes in public transportation workers exposed to trauma in the Stockholm train system
in Psychiatry research. Neuroimaging (Print); Elsevier Ireland Ltd., Clare (Irlanda)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Looi JCL, Mallerc JJ, Pagani M, Högberg G, Lindberg O, Liberg B, Botes L, Engman EL, Zhang Y, Svensson L, Wahlund LO (literal)

Pagina inizio

138 (literal)

Pagina fine

143 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

171 (literal)

Rivista

Psychiatry research. Neuroimaging (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

doi:10.1016/j.pscychresns.2008.03.011 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

6 (literal)

Note

ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

Research Centre for the Neurosciences of Ageing, Academic Unit of Psychological Medicine, Australian National University Medical School, The Canberra Hospital, Canberra, Australia Karolinska Institute, Department of Neurobiology, Caring Sciences & Society, Division of Clinical Geriatrics, Huddinge, Stockholm, Sweden Alfred Psychiatry Research Centre, Monash University, Melbourne, Australia Centre for Mental Health Research, Australian National University, Canberra, Australia Institute of Cognitive Sciences and Technologies, CNR, Rome, Italy Department of Nuclear Medicine, Karolinska Hospital, Solna, Stockholm, Sweden Department of Clinical Neuroscience, Section for Psychiatry, Huddinge, Karolinska Institute, Stockholm, Sweden Karolinska University Hospital, Hospital Physics & Radiology, Huddinge, Stockholm, Sweden (literal)

Titolo

Caudate volumes in public transportation workers exposed to trauma in the Stockholm train system (literal)

Abstract

The caudate nucleus is a structure implicated in the neural circuitry of psychological responses to trauma. This study aimed to quantify the volume of the caudate in persons exposed to trauma. Thirty-six subjects under 65 were recruited from transport workers in Stockholm who reported having been unintentionally responsible for a person-under-the-train accident or among employees having experienced an assault in their work (19992001) between 3 months and 6 years before MRI scanning. In those exposed to the trauma, a DSM-IV diagnosis of post-traumatic stress disorder (PTSD) wasmade by an independent psychiatrist,with subjects being classified as PTSD or no PTSD.MRI datawere analyzed blindly to all clinical information by an experienced rater using a standardizedmanual tracing protocol to quantify the volume of the caudate.Within-group comparisons of PTSD (n=19) and no PTSD (n=17) found the right caudate nucleus to be significantly (9%) larger than the left: a right hemisphere baseline asymmetry.Amultivariate analysis of covariance (MANCOVA)was conducted to assess the volume of the caudate nucleus (right and left) in relation to the diagnosis of no PTSD (n=17) or PTSD (n=19). After adjustment for the covariates (age, sex, intracranial volume, years since trauma, and number of trauma episodes), there was a significant difference in raw right caudate nucleus volume between subjects with PTSD compared with those without PTSD. Volume of the left caudate nucleus was not significantly different between the PTSD and no PTSD groups. The right caudate volume in the PTSD group was 9% greater compared with the no PTSD group. There is a larger right hemisphere volume of the caudate within those exposed to trauma with active PTSD compared with those without PTSD, superimposed upon a baseline caudate asymmetry. (literal)

Editore