Regional cerebral blood flow during auditory recall in 47 subjects exposed to assaultive and non-assaultive trauma and developing or not Post Traumatic Stress Disorder (Articolo in rivista)

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  • Regional cerebral blood flow during auditory recall in 47 subjects exposed to assaultive and non-assaultive trauma and developing or not Post Traumatic Stress Disorder (Articolo in rivista) (literal)
Anno
  • 2005-01-01T00:00:00+01:00 (literal)
Alternative label
  • Pagani M; Högberg G; Salmaso D; Tärnell B; Sanchez-Crespo A; Soares J; Åberg-Wistedt A; Jacobsson H; Hällström T; Larsson SA; Sundin Ö (2005)
    Regional cerebral blood flow during auditory recall in 47 subjects exposed to assaultive and non-assaultive trauma and developing or not Post Traumatic Stress Disorder
    in European archives of psychiatry and clinical neuroscience
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Pagani M; Högberg G; Salmaso D; Tärnell B; Sanchez-Crespo A; Soares J; Åberg-Wistedt A; Jacobsson H; Hällström T; Larsson SA; Sundin Ö (literal)
Pagina inizio
  • 359 (literal)
Pagina fine
  • 365 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 255 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Section of Nuclear Medicine and Department of Radiology, Karolinska Hospital, Stockholm, Sweden Institute of Cognitive Sciences and Technologies, CNR, Rome, Italy NEUROTEC, Division of Psychiatry, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden Department of Clinical Neuroscience, Karolinska Institutet, Karolinska Hospital, Stockholm, Sweden (literal)
Titolo
  • Regional cerebral blood flow during auditory recall in 47 subjects exposed to assaultive and non-assaultive trauma and developing or not Post Traumatic Stress Disorder (literal)
Abstract
  • Objective Psychological trauma leads to Post Traumatic Stress Disorder (PTSD) in susceptible subjects. The aim of this study was to investigate the differences in regional cerebral blood flow (rCBF) between two groups of subjects exposed to different types of traumatic stressor either developing or not PTSD. Method Twenty subjects developing (S) and 27 not developing (NS) PTSD after being exposed to either earlier person-under-the-train accident (NA) or being assaulted in the underground enviroment (A) were included in the study. 99mTc-HMPAO SPECT was performed and the uptake in 29 regions of the brain (VOIs), bilaterally, was assessed. rCBF distribution was compared, using analysis of variance (ANOVA), between groups (S/NS) and type (A/NA) during a situation involving an auditory evoked re-experiencing of the traumatic event. Discriminant analysis was applied to test the concordance between clinical diagnosis and SPECT findings. Results In the general analyses significant differences were found between groups and types and there was a significant hemispheres x types interaction. S showed higher CBF than NS and so did A as compared to NA, particularly in the right hemisphere. Discriminant analysis correctly classified 66% of cases (p<0.001) in testing S/NS and 72% (p<0.001) in testing NA/A. Conclusions Under recall of their traumatic experience we found higher relative CBF distribution values in S as compared to NS. CBF was higher in the right hemisphere and particularly in assaulted subjects. These findings underscore the role upon trauma recall of both right hemisphere and nature of stressing event. (literal)
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