Herpes Simplex virus disrupts NF-kB regulation by blocking its recruitment on the IkBa promoter and directing the factor on viral genes. (Articolo in rivista)

Type
Label
  • Herpes Simplex virus disrupts NF-kB regulation by blocking its recruitment on the IkBa promoter and directing the factor on viral genes. (Articolo in rivista) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1074/jbc.M512366200 (literal)
Alternative label
  • Amici C.(1)*; Rossi A.(2)*; Costanzo A.(3)*; Ciafre S.(2); Marinari M.(3); Balsamo M.(1); Levrero M.(4); Santoro M.G.(1,2) (2006)
    Herpes Simplex virus disrupts NF-kB regulation by blocking its recruitment on the IkBa promoter and directing the factor on viral genes.
    in The Journal of biological chemistry (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Amici C.(1)*; Rossi A.(2)*; Costanzo A.(3)*; Ciafre S.(2); Marinari M.(3); Balsamo M.(1); Levrero M.(4); Santoro M.G.(1,2) (literal)
Pagina inizio
  • 7110 (literal)
Pagina fine
  • 7117 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
  • **These authors contributed equally Impact Factor = 5.808 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 281 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 11 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1-Department of Biology University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy; 2- Institute of Neurobiology and Molecular Medicine, CNR, 00133 Rome, Italy; 3-Department of Dermatology University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy; 4- Department of Internal Medicine, University of Rome La Sapienza, 00185 Rome, Italy. * These authors contributed equally to this work. (literal)
Titolo
  • Herpes Simplex virus disrupts NF-kB regulation by blocking its recruitment on the IkBa promoter and directing the factor on viral genes. (literal)
Abstract
  • Herpes simplex viruses (HSVs) are able to hijack the host-cell IkappaB kinase (IKK)/NF-kappaB pathway, which regulates critical cell functions from apoptosis to inflammatory responses; however, the molecular mechanisms involved and the outcome of the signaling dysregulation on the host-virus interaction are mostly unknown. Here we show that in human keratinocytes HSV-1 attains a sophisticated control of the IKK/NF-kappaB pathway, inducing two distinct temporally controlled waves of IKK activity and disrupting the NF-kappaB autoregulatory mechanism. Using chromatin immunoprecipitation we demonstrate that dysregulation of the NF-kappaB-response is mediated by a virus-induced block of NF-kappaB recruitment to the promoter of the IkappaBalpha gene, encoding the main NF-kappaB-inhibitor. We also show that HSV-1 redirects NF-kappaB recruitment to the promoter of ICP0, an immediate-early viral gene with a key role in promoting virus replication. The results reveal a new level of control of cellular functions by invading viruses and suggest that persistent NF-kappaB activation in HSV-1-infected cells, rather than being a host response to the virus, may play a positive role in promoting efficient viral replication. (literal)
Prodotto di
Autore CNR

Incoming links:


Autore CNR di
Prodotto
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
data.CNR.it