Distinct profiles of beta-lactoglobulin specific, secondary immune response in the peripheral blood of children with IgE-, non IgE-mediated cow’s milk allergy, and of those who outgrew allergy. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Distinct profiles of beta-lactoglobulin specific, secondary immune response in the peripheral blood of children with IgE-, non IgE-mediated cow’s milk allergy, and of those who outgrew allergy. (Articolo in rivista) (literal)

Anno

• 2011-01-01T00:00:00+01:00 (literal)

Alternative label

• IMMACOLATA VOCCA; ROBERTO BERNI CANANI; ALESSANDRA CAMARCA; SERENA RUOTOLO; RITA NOCERINO; GIORGIA RADANO; ANDREA DEL MASTRO; RICCARDO TRONCONE; AND CARMEN GIANFRANI (2011)
  Distinct profiles of beta-lactoglobulin specific, secondary immune response in the peripheral blood of children with IgE-, non IgE-mediated cow’s milk allergy, and of those who outgrew allergy.
  in Pediatric research
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• IMMACOLATA VOCCA; ROBERTO BERNI CANANI; ALESSANDRA CAMARCA; SERENA RUOTOLO; RITA NOCERINO; GIORGIA RADANO; ANDREA DEL MASTRO; RICCARDO TRONCONE; AND CARMEN GIANFRANI (literal)

Pagina inizio

• 549 (literal)

Pagina fine

• 554 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 70 (literal)

Rivista

• Pediatric research (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 6 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Institute of Food Sciences [I.V., A.C., G.R., C.G.], CNR, Avellino 83100, Italy; Department of Pediatrics and European Laboratory for the Investigation of Food-Induced Diseases [R.B.C., S.R., R.N., A.D.M., R.T.], University \"Federico II\" of Naples, Naples 80131, Italy (literal)

Titolo

• Distinct profiles of beta-lactoglobulin specific, secondary immune response in the peripheral blood of children with IgE-, non IgE-mediated cow’s milk allergy, and of those who outgrew allergy. (literal)

Abstract

• Several studies analyzing the immune responses in patients with cow's milk allergy (CMA) have used T-cell lines or T-cell clones that require prolonged in vitro cell culturing and may result in a switched cell phenotype and function. We investigated immune responses to beta-lactoglobulin (b-LG) in peripheral blood mononuclear cells after a short in vitro antigen stimulation in children with acute CMA (both IgE-mediated and non-IgE-mediated forms) and in those who outgrew an IgE-mediated CMA. Healthy controls were also investigated. Peripheral blood mononuclear cells were assayed for IL-13, IFN-?, IL-4, and IL-10. Although b-LG induced a cytokine production and/or cell proliferation almost in all children, included healthy controls, differences were observed among the four groups. Children with IgE-mediated CMA had a marked Th2-response, with high IL-13 production and proliferation, but low IFN-?; by contrast, children with non-IgE-mediated CMA produced no, or very low, IL-13 and cell proliferation. Children, who outgrew CMA, showed a shift to a Th1-response, with reduced IL-13 and increased IFN-?. IL-10-responses were high in all groups, with the highest level in healthy children; by contrast, IL-4 was undetectable in all children. This study highlights the use of shortly stimulated peripheral blood cells to investigate the food-induced immune responses. (literal)

Prodotto di

• Institute of food sciences (ISA) (Istituto)
• Bioassay cellulari per l’analisi della proprietà immunostimolanti degli alimenti (AG.P05.005.008) (Modulo)
• Tecnologie, Tracciabilità e Sicurezza degli Alimenti (AG.P05.004.001) (Modulo)
• Alimenti e salute dell'uomo (AG.P05.005.001) (Modulo)

Autore CNR

• CARMELA GIANFRANI (Unità di personale interno)

Incoming links:

Prodotto

• Institute of food sciences (ISA) (Istituto)
• Tecnologie, Tracciabilità e Sicurezza degli Alimenti (AG.P05.004.001) (Modulo)
• Alimenti e salute dell'uomo (AG.P05.005.001) (Modulo)
• Bioassay cellulari per l’analisi della proprietà immunostimolanti degli alimenti (AG.P05.005.008) (Modulo)

Autore CNR di

• CARMELA GIANFRANI (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Pediatric research (Rivista)