Phenolic compound characterisation and antiproliferative activity of ‘‘Annurca” apple, a southern Italian cultivar (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Phenolic compound characterisation and antiproliferative activity of ‘‘Annurca” apple, a southern Italian cultivar (Articolo in rivista) (literal)

Anno

• 2010-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.foodchem.2010.04.023 (literal)

Alternative label

• Mari A.; Tedesco I.; Nappo A.; Russo G. L.; Malorni A.; Carbone, V. (2010)
  Phenolic compound characterisation and antiproliferative activity of ‘‘Annurca” apple, a southern Italian cultivar
  in Food chemistry
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Mari A.; Tedesco I.; Nappo A.; Russo G. L.; Malorni A.; Carbone, V. (literal)

Pagina inizio

• 157 (literal)

Pagina fine

• 164 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 123 (literal)

Rivista

• Food chemistry (Rivista)

Note

• Scopu (literal)
• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Proteomic and Biomolecular Mass Spectrometry Center, Institute of Food Sciences, National Research Council, Via Roma, 64, 83100 Avellino, Italy BJ Laboratory, Institute of Food Sciences, National Research Council, Via Roma, 64, 83100 Avellino, Italy (literal)

Titolo

• Phenolic compound characterisation and antiproliferative activity of ‘‘Annurca” apple, a southern Italian cultivar (literal)

Abstract

• In Annurca apples, a southern Italian variety, polyphenols were studied. The phenolic composition of Annurca apple peel was determined by HPLC coupled with electrospray negative ionisation multistage ion trap mass spectrometry (HPLC/ESI-ITMSⁿ). In addition, the antiproliferative and pro-apoptotic activities of peel extracts enriched in polyphenols and prepared from Annurca (APE), Red Delicious (RDPE) and Golden Delicious (GPE) varieties were evaluated on an HL-60 cell line. APE exhibited the highest total phenol content among the three apple cultivars tested, as determined by Folin-Ciocalteau's procedure and HPLC-UV analysis. APE also showed higher amounts of chlorogenic acid, procyanidins, flavonols, dihydrochalcones and cyanidin-3-O-galactoside than GPE or RDPE. All three apple extracts were able to significantly decrease cell viability, from 50% to 80%, with APE appearing the most effective, while GPE was the least cytotoxic among the three samples. Similarly, APE and RDPE induced a significant increase of caspase-3 activity, whose activation represents a hallmark of apoptosis. (literal)

Prodotto di

• Institute of food sciences (ISA) (Istituto)
• Metodologie di Spettrometria di Massa, Proteomica, Metabolomica e Bioinformatica nelle Scienze dell'Alimentazione (AG.P05.003.001) (Modulo)
• Alimenti e salute dell'uomo (AG.P05.005.001) (Modulo)

Autore CNR

• ANTONIO MALORNI (Unità di personale interno)
• ANNUNZIATA NAPPO (Persona)
• GIAN LUIGI RUSSO (Persona)
• VIRGINIA CARBONE (Unità di personale interno)
• ANGELA MARI (Persona)

Insieme di parole chiave

• Keywords of "Phenolic compound characterisation and antiproliferative activity of ‘‘Annurca” apple, a southern Italian cultivar" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of food sciences (ISA) (Istituto)
• Metodologie di Spettrometria di Massa, Proteomica, Metabolomica e Bioinformatica nelle Scienze dell'Alimentazione (AG.P05.003.001) (Modulo)
• Alimenti e salute dell'uomo (AG.P05.005.001) (Modulo)

Autore CNR di

• GIAN LUIGI RUSSO (Persona)
• ANTONIO MALORNI (Unità di personale interno)
• VIRGINIA CARBONE (Unità di personale interno)
• ANNUNZIATA NAPPO (Persona)
• ANGELA MARI (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Food chemistry (Rivista)

Insieme di parole chiave di

• Keywords of "Phenolic compound characterisation and antiproliferative activity of ‘‘Annurca” apple, a southern Italian cultivar" (Insieme di parole chiave)