The retinoblastoma-related Rb2/p130 gene is an effector downstream of AP-2 during neural differentiation. (Articolo in rivista)

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Label
  • The retinoblastoma-related Rb2/p130 gene is an effector downstream of AP-2 during neural differentiation. (Articolo in rivista) (literal)
Anno
  • 2001-01-01T00:00:00+01:00 (literal)
Alternative label
  • Paggi M.G. 1, Bonetto F. 2, Severino A. 3, Baldi A. 4, Battista T. 5, Bucci F. 6, Felsani A. 7, Lombardi D. 8, Giordano A. 9 (2001)
    The retinoblastoma-related Rb2/p130 gene is an effector downstream of AP-2 during neural differentiation.
    in Oncogene (Basingstoke)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Paggi M.G. 1, Bonetto F. 2, Severino A. 3, Baldi A. 4, Battista T. 5, Bucci F. 6, Felsani A. 7, Lombardi D. 8, Giordano A. 9 (literal)
Pagina inizio
  • 2570 (literal)
Pagina fine
  • 2578 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
  • Impact Factor 2002: 5.979 (literal)
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  • 20 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1,2,3,4,5,8 Istituto Regina Elena-Roma, 6,7 CNR-INMM, 9 Temple University- Philadelphia (literal)
Titolo
  • The retinoblastoma-related Rb2/p130 gene is an effector downstream of AP-2 during neural differentiation. (literal)
Abstract
  • Rb2/p130, a member of the Retinoblastoma family of growth and tumour suppressor genes, is extensively implicated in the control of cell cycle and differentiation. The minimal promoter region of Rb2/p130 in T98G human glioblastoma cells was identified and its analysis revealed the presence of a KER1 palindromic sequence able to bind the transcription factor AP-2, a regulatory protein that plays a crucial role in ectodermal differentiation. This KER1 site interacted in vitro with AP-2, and AP-2 overexpression increased Rb2/p130 transcription and translation. We also found that rat PC12 pheochromocytoma cells, when induced to differentiate by NGF, displayed an increase of AP-2 protein levels and of Rb2/p130 transcription and protein levels. AP-2-transfected PC12 cells displayed enhanced transcription and translation of Rb2/p130 and of the cdk inhibitor p21(WAF1/CIP1), a gene known to be under the control of AP-2, but unable by itself to elicit PC12 differentiation. Overexpression of either AP-2 or Rb2/p130 elicited per se cell differentiation in the absence of NGF, while coexpression of AP-2B, a negative regulator of AP-2 transcriptional activity, inhibited only AP-2-induced differentiation. Altogether, these results indicate that Rb2/p130 is a critical effector of AP-2 in sustaining ectodermal differentiation (literal)
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