Gastrokine 1 expression in patients with and without Helicobacter pylori infection. (Articolo in rivista)

Type
Label
  • Gastrokine 1 expression in patients with and without Helicobacter pylori infection. (Articolo in rivista) (literal)
Anno
  • 2007-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.dld.2006.09.017 (literal)
Alternative label
  • Nardone G; Rippa E; Martin G; Rocco A; Siciliano RA; Fiengo A; Cacace G; Malorni A; Budillon G; Arcari P. (2007)
    Gastrokine 1 expression in patients with and without Helicobacter pylori infection.
    in Digestive and Liver Disease
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Nardone G; Rippa E; Martin G; Rocco A; Siciliano RA; Fiengo A; Cacace G; Malorni A; Budillon G; Arcari P. (literal)
Pagina inizio
  • 122 (literal)
Pagina fine
  • 129 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 39 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 8 (literal)
Note
  • ISI Web of Science (WOS) (literal)
  • PubMe (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Dipartimento di Medicina Clinica e Sperimentale, Unità di Gastroenterologia, Universit`a di Napoli Federico II, Naples, Italy Dipartimento di Biochimica e Biotecnologie Mediche, Università di Napoli Federico II, Naples, Italy Centro di Spettrometria di Massa Proteomica e Biomolecolare, Istituto di Scienze dell’Alimentazione—CNR, Avellino, Italy CEINGE Biotecnologie Avanzate Scarl, Naples, Italy (literal)
Titolo
  • Gastrokine 1 expression in patients with and without Helicobacter pylori infection. (literal)
Abstract
  • BACKGROUND: To understand the molecular changes underlying Helicobacter pylori-related gastric diseases is mandatory to prevent gastric cancer. Proteomic technology is providing a rapid expansion of the basic knowledge, particularly in the discovery of new biomarkers involved in the tumourigenesis. AIM: To characterise changes in protein expression level of the gastric mucosa in H. pylori-infected patients. METHODS: The population enrolled comprised 41 dyspeptic patients. Proteins extracted from gastric mucosal specimens were analysed by 2-dimensional electrophoresis, sequenced by MALDI-TOF and identified by Edman's degradation. RESULTS: Twenty-one out of 41 patients had H. pylori infection of whom 17 had anti-CagA IgG antibodies. Several proteins were identified, of which Rho guanosine diphosphatase dissociation inhibitor alpha and heat shock protein 27 increased and glutathione transferase and antrum mucosa protein-18 decreased in H. pylori-positive in respect to H. pylori-negative patients. Interestingly, antrum mucosa protein-18, currently referred as gastrokine-1, showed two isoforms differing in the first N-terminal amino acid residue. Both gastrokine-1 isoforms were observed in the H. pylori-negative group whereas a lower expression or even absence of the gastrokine-1 basic isoform was found in a subgroup (7/21) of H. pylori-positive patients with moderate-severe gastritis. CONCLUSION: Our study demonstrated the presence of gastrokine-1 isoforms of which the basic isoform was reduced in a subset of patients with H. pylori infection. (literal)
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