Identification of a peptide from a-gliadin resistant to digestive enzymes: implications for celiac disease (Articolo in rivista)

Type
Label
  • Identification of a peptide from a-gliadin resistant to digestive enzymes: implications for celiac disease (Articolo in rivista) (literal)
Anno
  • 2007-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.jchromb.2009.11.033 (literal)
Alternative label
  • Mamone G, Ferranti P, Rossi M, Roepstrorff P, Fierro O, Malorni A, Addeo F. (2007)
    Identification of a peptide from a-gliadin resistant to digestive enzymes: implications for celiac disease
    in Journal of chromatography. B (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Mamone G, Ferranti P, Rossi M, Roepstrorff P, Fierro O, Malorni A, Addeo F. (literal)
Pagina inizio
  • 236 (literal)
Pagina fine
  • 241 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 855 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
  • PubMe (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Proteomic and Biomolecular Mass Spectrometry Centre, Institute of Food Science CNR, Avellino, Italy Department of Food Science, University of Naples ‘Federico II’, Portici (NA), Italy Lab of Immunobiology, Institute of Food Science CNR, Avellino, Italy Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark Lab of Food Chemistry and Technology, Institute of Food Science CNR, Avellino, Italy (literal)
Titolo
  • Identification of a peptide from a-gliadin resistant to digestive enzymes: implications for celiac disease (literal)
Abstract
  • Current knowledge indicates that both innate and adaptive immune responses are involved in Celiac disease (CD) driven by different gliadin peptides. By studying a representative recombinant alpha-gliadin form, a further 25-mer peptide resistant to gastric, pancreatic, and human intestinal brush-border membrane enzymes was detected. This peptide latter encompasses the sequence 31-43 known to elicit the innate immune response in CD. The resistance of 25-mer, as well as that of the already described 33-mer related to the CD adaptive immune response, was confirmed on a standard flour wheat sample representative of the most widespread European varieties. (literal)
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