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Real-time contrast-enhanced specific ultrasound in staging and follow-up of splenic lymphomas. (Articolo in rivista)

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Real-time contrast-enhanced specific ultrasound in staging and follow-up of splenic lymphomas. (Articolo in rivista) (literal)

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Tafuto S, Catalano O, Barba G, Sandomenico F, Lo bianco R, Tortoriello A, Formato R, Comella P, Siani A, Di Meo M, Iaffaioli RV, and Quattrin S. (2006)
Real-time contrast-enhanced specific ultrasound in staging and follow-up of splenic lymphomas.
in Frontiers in bioscience (Print)
(literal)

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Tafuto S, Catalano O, Barba G, Sandomenico F, Lo bianco R, Tortoriello A, Formato R, Comella P, Siani A, Di Meo M, Iaffaioli RV, and Quattrin S. (literal)

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1 Department of Medical Oncology,S. Maria delle Grazie Hospital Pozzuoli, Italy; 2 Department of Radiology, National Cancer Institute, Naples,Italy, 3 Epidemiology and Population Genetics, Institute of Food Science, Avellino, Italy; 4 Department of Radiology, S. Maria delle Grazie Hospital Pozzuoli, Italy; 5 Department of Medical Oncology, National Cancer Institute, Naples. Italy (literal)

Titolo

Real-time contrast-enhanced specific ultrasound in staging and follow-up of splenic lymphomas. (literal)

Abstract

From January 2003 to April 2005 we studied 25 lymphoma patients (10 with HD, 4 with low-grade NHL, 6 with high-grade NHL and 5 with chronic lymphatic leukaemia; 14 men, 11 women, age range 28-79 years). After a baseline US study we rapidly injected 4.8 mL of the second-generation microbubble contrast agent SonoVue (Bracco, Italy). Contrast enhanced studies were carried out with the contrast-specific software named Contrast Tuned Imaging (Esaote, Italy) using a continuous, harmonic acquisition and a low acoustic pressure. The CS-US findings were correlated with results of standard tools, including CT, MRI, US follow up. CS-US revealed correctly 47 out of the 52 lesions identified by CT scan, in the absence of false positive findings (sensitivity = 90%; Specificity = 100%, in comparison to CT scan). Complete concordance in evaluating the lesion extension of the CS-US in respect to CT was 88%, while underestimate occurred in 9% and overestimate in 3% of cases. On the contrary, basic sonography defined correctly the dimensional alteration in 52% of the cases, underestimated in 35% and overestimated in 13%, thus showing significantly lower accuracy (chi-square = 30.0, p < 0.001). In our experience, CS-US was superior to conventional sonography even from a qualitative point of view. (literal)

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