Synthesis and antiproliferative activity of A-ring aromatised and conduritol-like steroidal compounds. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Synthesis and antiproliferative activity of A-ring aromatised and conduritol-like steroidal compounds. (Articolo in rivista) (literal)

Anno

• 2005-01-01T00:00:00+01:00 (literal)

Alternative label

• Milic D., Kop T., Juranic Z., Gasic M. J., Tinant B., Pocsfalvi G., Solaja B. A. (2005)
  Synthesis and antiproliferative activity of A-ring aromatised and conduritol-like steroidal compounds.
  in Steroids
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Milic D., Kop T., Juranic Z., Gasic M. J., Tinant B., Pocsfalvi G., Solaja B. A. (literal)

Pagina inizio

• 922 (literal)

Pagina fine

• 932 (literal)

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• 1 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 70 (literal)

Rivista

• Steroids (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Univ Belgrade, Fac Chem, Belgrade 11000, Serbia Monteneg; Inst Oncol & Radiol Serbia, Belgrade 11000, Serbia Monteneg; Dept Chim, Unite CSTR, B-1348 Louvain, Belgium; CNR, Ist Sci Alimentaz, Ctr Spettrometria Massa Proteom & Biomol, Avellino, Italy (literal)

Titolo

• Synthesis and antiproliferative activity of A-ring aromatised and conduritol-like steroidal compounds. (literal)

Abstract

• A simple approach to aromatization of steroidal quinols and epoxyquinols using a catalytic amount of TMSOTf is reported. Beside acetylation of the angular OH, the acid-catalyzed (TfOH) dienone-phenol rearrangement occurred affording \"para\" products, or in the case of blocked position 4, the acetoxy group 1,2-migration leads to the formation of \"meta\" products. Using epoxyquinol derivative as a substrate, the acetoxy group elimination was observed, followed by acid-catalyzed epoxy-ring opening and subsequent double bond migration, giving as a final product Delta(9,11)A-ring aromatized compounds. Synthesis of conduritol-like compounds and structure confirmation by X-ray crystallography of the precursor of steroidal conduritol is also described. In addition, the results of extensive antiproliferative screening against a panel of 60 cancer cell lines are presented. (literal)

Prodotto di

• Institute of food sciences (ISA) (Istituto)
• Metodologie di Spettrometria di Massa, Proteomica, Metabolomica e Bioinformatica nelle Scienze dell'Alimentazione (AG.P05.003.001) (Modulo)

Autore CNR

• GABRIELLA KATALIN POCSFALVI (Persona)

Incoming links:

Prodotto

• Institute of food sciences (ISA) (Istituto)
• Metodologie di Spettrometria di Massa, Proteomica, Metabolomica e Bioinformatica nelle Scienze dell'Alimentazione (AG.P05.003.001) (Modulo)

Autore CNR di

• GABRIELLA KATALIN POCSFALVI (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Steroids (Rivista)