Conjugated linoleic acid-mediated apoptosis in Jurkat T cells involves the production of reactive oxygen species. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Conjugated linoleic acid-mediated apoptosis in Jurkat T cells involves the production of reactive oxygen species. (Articolo in rivista) (literal)

Anno

• 2004-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1159/000076927 (literal)

Alternative label

• Bergamo P; Luongo D; Rossi M. (2004)
  Conjugated linoleic acid-mediated apoptosis in Jurkat T cells involves the production of reactive oxygen species.
  in Cellular physiology and biochemistry (Online)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Bergamo P; Luongo D; Rossi M. (literal)

Pagina inizio

• 57 (literal)

Pagina fine

• 64 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• La rivista è pubblicata anche cartacea con ISSN: 1015-8987 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 14 (literal)

Rivista

• Cellular physiology and biochemistry (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1-2 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• CNR (literal)

Titolo

• Conjugated linoleic acid-mediated apoptosis in Jurkat T cells involves the production of reactive oxygen species. (literal)

Abstract

• he pro-apoptotic ability of conjugated linoleic acid (CLA) has been partly accounted for its anticarcinogenic effect although the precise mechanism of action remains elusive. In this study we characterized the biochemical events governing CLA-mediated apoptosis in Jurkat T cells. CLA induced a time-and dose-dependent activation of caspase-3. Pre-treatment with antioxidant molecules (trolox and quercetin), antioxidant enzymes (catalase and superoxide dismutase) metal chelator (EDTA), reducing agent (N-acetyl-L-cysteine), NADPH oxidase or protein kinase C (PKC) inhibitor (diphenyleneiodinium and G 6976, respectively) suppressed CLA-mediated caspase-3 activation. Moreover, CLA treatment increased the NADPH oxidase activity and depleted the intracellular pool of reduced glutathione. These results suggested that CLA can trigger apoptosis through an oxidative stress mediated by the PKC/NADPH oxidase pathway. The proposed mechanism provides a new insight into the anticancer activity of CLA. (literal)

Prodotto di

• Institute of food sciences (ISA) (Istituto)

Autore CNR

• MAURO ROSSI (Unità di personale interno)
• DIOMIRA LUONGO (Persona)
• PAOLO BERGAMO (Unità di personale interno)

Incoming links:

Prodotto

• Institute of food sciences (ISA) (Istituto)

Autore CNR di

• PAOLO BERGAMO (Unità di personale interno)
• MAURO ROSSI (Unità di personale interno)
• DIOMIRA LUONGO (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Cellular physiology and biochemistry (Rivista)