http://www.cnr.it/ontology/cnr/individuo/prodotto/ID4515

Umbilical cord Interleukin-6 levels are elevated in term neonates with perinatal asphyxia. (Articolo in rivista)

Type

Articolo in rivista (Classe)
Prodotto della ricerca (Classe)

Label

Umbilical cord Interleukin-6 levels are elevated in term neonates with perinatal asphyxia. (Articolo in rivista) (literal)

Anno

2003-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1046/j.1365-2362.2003.01136.x (literal)

Alternative label

Chiesa C. 1) Pellegrini G. 2) Panero A. 3) De Luca T. 3) Assumma M. 2) Signore F. 4) Pacifico L. 3) (2003)
Umbilical cord Interleukin-6 levels are elevated in term neonates with perinatal asphyxia.
in European journal of clinical investigation (Print); Blackwell publishing, Oxford (Regno Unito)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Chiesa C. 1) Pellegrini G. 2) Panero A. 3) De Luca T. 3) Assumma M. 2) Signore F. 4) Pacifico L. 3) (literal)

Pagina inizio

352 (literal)

Pagina fine

358 (literal)

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33 (literal)

Rivista

European journal of clinical investigation (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

7 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

4 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto

Pubblicazione (literal)

Note

Scopu (literal)
PubMe (literal)
ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

1) Institute of Neurobiology and Molecular Medicine, National Research Council,Rome, Italy 2) Division of Neonatology, S. Camillo Hospital,Rome, Italy 3) Institute of Pediatrics, \"Sapienza\" University of Rome,Italy 4) Division of Obstetrics, S. Camillo Hospital,Rome, Italy (literal)

Titolo

Umbilical cord Interleukin-6 levels are elevated in term neonates with perinatal asphyxia. (literal)

Abstract

Background: A correlation between elevation of pro-inflammatory cytokines and white matter injury or abnormal neurologic outcome has been established in the preterm infant. In the full-term neonate, few studies exist linking elevation of cytokines with encephalopathy and poor neurodevelopmental outcome. Our aims were to investigate if serum interleukin-6 concentrations in delivering mothers and their offspring at birth are associated with perinatal asphyxia, and to examine the relation of interleukin-6 levels to the severity of hypoxic-ischemic encephalopathy and to the neurological outcome. Design and methods: Serum interleukin-6 levels were measured at birth, 24 and 48 h of life in 50 consecutive term uninfected newborns with perinatal asphyxia and 113 randomly selected healthy term newborns, and at delivery in their mothers. Results: The median cord interleukin-6 concentrations in the infants who developed hypoxic-ischemic encephalopathy was 376-fold as high as the values in the normal infants (P < 0.0001) and 5.5-fold as high as those in the infants with asphyxia who did not develop hypoxic-ischemic encephalopathy (P < 0.05). There was also a significant relationship between interleukin-6 and the degree of hypoxic-ischemic encephalopathy, and between interleukin-6 and neurodevelopmental outcome at 2 years of age. Regardless of outcome, in the asphyxiated infants the interleukin-6 values were significantly lower at both 24 and 48 h of life than at birth, with a significant decline from 24 to 48 h of life. Among mothers of the asphyxiated neonates, there were no significant differences in interleukin-6 concentrations between those delivering neonates with and without hypoxic-ischemic encephalopathy. Conclusions: Measurement of IL-6 concentrations in the umbilical cord of neonates with perinatal asphyxia may be useful to identify early, and in a relatively simple way, those who are most likely to have subsequent brain injury and adverse outcome. (literal)

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