Presence of nerve growth factor and TrkA expression in the SVZ of EAE rats: evidence for a possible functional significance (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Presence of nerve growth factor and TrkA expression in the SVZ of EAE rats: evidence for a possible functional significance (Articolo in rivista) (literal)

Anno

• 2005-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.expneurol.2004.08.034 (literal)

Alternative label

• Triaca V.1, Tirassa P.2, Aloe L .3 (2005)
  Presence of nerve growth factor and TrkA expression in the SVZ of EAE rats: evidence for a possible functional significance
  in Experimental neurology
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Triaca V.1, Tirassa P.2, Aloe L .3 (literal)

Pagina inizio

• 53 (literal)

Pagina fine

• 64 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• Impact Factor = 3.767 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 191 (literal)

Rivista

• Experimental neurology (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1,2,3 = Institute of Neurobiology and Molecular Medicine, National Research Council (CNR), 00137 Rome, Italy (literal)

Titolo

• Presence of nerve growth factor and TrkA expression in the SVZ of EAE rats: evidence for a possible functional significance (literal)

Abstract

• Nerve growth factor (NGF) is a well-characterized neurotrophic factor that plays a crucial role during development in the growth, differentiation, and maintenance of brain neurons as well as in the reparative response of the adult brain to neuronal damage. Recent studies have shown that acute axonal loss occurs in multiple sclerosis (MS) and its animal model, experimental allergic encephalomyelitis (EAE), and that NGF suppresses clinical symptoms of EAE in nonhuman primates. Aim of the present study was to investigate the role of NGF in the regenerative response of the adult brain to neuronal damage occurring in EAE. Using EAE rats, we have found that exogenous NGF injection and NGF deprivation (NGF autoimmunization) can act on growth and differentiation of brain precursor cells in the subventricular zone (SVZ) of EAE rats. Moreover, NGF administration in brain of EAE rats stimulates the expression of early neuronal markers on proliferating precursor cells of the SVZ. The data obtained demonstrated that NGF and its antibody affect bromodeoxyuridine (BrdU) incorporation and NGF receptor expression by SVZ progenitor cells in the brain of EAE rats. (literal)

Prodotto di

• Funzioni del S.N./Neurotrofine (SV.P16.007.001) (Modulo)
• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)

Autore CNR

• PAOLA TIRASSA (Unità di personale interno)
• LUIGI ALOE (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Presence of nerve growth factor and TrkA expression in the SVZ of EAE rats: evidence for a possible functional significance" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)
• Funzioni del S.N./Neurotrofine (SV.P16.007.001) (Modulo)

Autore CNR di

• LUIGI ALOE (Unità di personale interno)
• PAOLA TIRASSA (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Experimental neurology (Rivista)

Insieme di parole chiave di

• Keywords of "Presence of nerve growth factor and TrkA expression in the SVZ of EAE rats: evidence for a possible functional significance" (Insieme di parole chiave)