Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkB kinase (IKK). (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkB kinase (IKK). (Articolo in rivista) (literal)

Anno

• 2000-01-01T00:00:00+01:00 (literal)

Alternative label

• Antonio Rossi (1); Pankaj Kapahi(2); Gioacchino Natoli(2); Takayuki Takahashi(2); Yi Chen(2); Michael Karin(2); M. Gabriella Santoro(1,3) (2000)
  Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkB kinase (IKK).
  in Nature (Lond.)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Antonio Rossi (1); Pankaj Kapahi(2); Gioacchino Natoli(2); Takayuki Takahashi(2); Yi Chen(2); Michael Karin(2); M. Gabriella Santoro(1,3) (literal)

Pagina inizio

• 103 (literal)

Pagina fine

• 108 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 403 (literal)

Rivista

• Nature (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1-Institute of Experimental Medicine, CNR, Rome Italy 2- Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California San Diego, La Jolla, California,USA 3- Laboratory of Virology, Department of Biology, University of Rome Tor Vergata, Rome, Italy (literal)

Titolo

• Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkB kinase (IKK). (literal)

Abstract

• NF-kappaB is a critical activator of genes involved in inflammation and immunity. Pro-inflammatory cytokines activate the IkappaB kinase (IKK) complex that phosphorylates the NF-kappaB inhibitors, triggering their conjugation with ubiquitin and subsequent degradation. Freed NF-kappaB dimers translocate to the nucleus and induce target genes, including the one for cyclo-oxygenase 2 (COX2), which catalyses the synthesis of pro-inflammatory prostaglandins, in particular PGE. At late stages of inflammatory episodes, however, COX2 directs the synthesis of anti-inflammatory cyclopentenone prostaglandins, suggesting a role for these molecules in the resolution of inflammation. Cyclopentenone prostaglandins have been suggested to exert anti-inflammatory activity through the activation of peroxisome proliferator-activated receptor-gamma. Here we demonstrate a novel mechanism of antiinflammatory activity which is based on the direct inhibition and modification of the IKKbeta subunit of IKK. As IKKbeta is responsible for the activation of NF-kappaB by pro-inflammatory stimuli, our findings explain how cyclopentenone prostaglandins function and can be used to improve the utility of COX2 inhibitors (literal)

Prodotto di

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)

Autore CNR

• MARIA GABRIELLA SANTORO (Unità di personale esterno)
• ANTONIO ROSSI (Persona)

Incoming links:

Prodotto

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)

Autore CNR di

• ANTONIO ROSSI (Persona)
• MARIA GABRIELLA SANTORO (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Nature (Rivista)