Biomimetic Mg-substituted hydroxyapatite: from synthesis to in vivo behaviour (Articolo in rivista)

Type
Label
  • Biomimetic Mg-substituted hydroxyapatite: from synthesis to in vivo behaviour (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1007/s10856-006-0032-y (literal)
Alternative label
  • Elena Landi; Giandomenico Logroscino; Luca Proietti; Anna Tampieri; Monica Sandri; Simone Sprio (2008)
    Biomimetic Mg-substituted hydroxyapatite: from synthesis to in vivo behaviour
    in Journal of materials science. Materials in medicine
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Elena Landi; Giandomenico Logroscino; Luca Proietti; Anna Tampieri; Monica Sandri; Simone Sprio (literal)
Pagina inizio
  • 239 (literal)
Pagina fine
  • 247 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.springerlink.com/content/j53536vkjv2w0803/?MUD=MP (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 19 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • In: Journal of Materials Science-Materials in Medicine, vol. 19 (1) pp. 239 - 247. Springer, 2008. (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Institute of Science and Technology for Ceramics, National Research Council, Via Granarolo, 64, Faenza, RA 48018, Italy Orthopaedic Department, Catholic University of Rome, largo F.Vito, 1, Rome 00168, Italy (literal)
Titolo
  • Biomimetic Mg-substituted hydroxyapatite: from synthesis to in vivo behaviour (literal)
Abstract
  • The incorporation of magnesium ions (in the range 5-10 mol% in respect to Ca) into the hydroxyapatite structure, which is of great interest for the developing of artificial bone, was performed using magnesium chloride, calcium hydroxide and phosphoric acid, as reactants. Among the synthesized powders, the synthetic HA powder containing 5.7% Mg substituting for calcium was selected, due to its better chemico-physical features, and transformed into granules of 400-600 micron, for biocompatibility tests (genotoxicity, carcinogenicity, toxicity, in vitro cytotoxicity and in vivo skin irritation-sensitization tests). In vivo tests were carried out on New Zealand White rabbits using the granulate as filling for a femoral bone defect: osteoconductivity and resorption were found to be enhanced compared to commercial stoichiometric HA granulate, taken as control. (literal)
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