http://www.cnr.it/ontology/cnr/individuo/prodotto/ID4197

Absence of the GPR37/PAEL receptor impairs striatal Akt and ERK2 phosphorylation, Delta FosB expression, and conditioned place preference to amphetamine and cocaine (Articolo in rivista)

Type

Articolo in rivista (Classe)
Prodotto della ricerca (Classe)

Label

Absence of the GPR37/PAEL receptor impairs striatal Akt and ERK2 phosphorylation, Delta FosB expression, and conditioned place preference to amphetamine and cocaine (Articolo in rivista) (literal)

Anno

2011-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1096/fj.10-175737 (literal)

Alternative label

Marazziti, Daniela; Di Pietro, Chiara; Mandillo, Silvia; Golini, Elisabetta; Matteoni, Rafaele; Tocchini-Valentini, Glauco P. (2011)
Absence of the GPR37/PAEL receptor impairs striatal Akt and ERK2 phosphorylation, Delta FosB expression, and conditioned place preference to amphetamine and cocaine
in The FASEB journal
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Marazziti, Daniela; Di Pietro, Chiara; Mandillo, Silvia; Golini, Elisabetta; Matteoni, Rafaele; Tocchini-Valentini, Glauco P. (literal)

Pagina inizio

2071 (literal)

Pagina fine

2081 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

25 (literal)

Rivista

?The ?FASEB journal (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

Published online before print March 3, 2011, doi:10.1096/fj.10-175737 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

11 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

6 (literal)

Note

ISI Web of Science (WoS) (literal)
ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

Consiglio Nazionale delle Ricerche (CNR) (literal)

Titolo

Absence of the GPR37/PAEL receptor impairs striatal Akt and ERK2 phosphorylation, Delta FosB expression, and conditioned place preference to amphetamine and cocaine (literal)

Abstract

The orphan G-protein-coupled receptor 37 (GPR37) colocalizes with the dopamine (DA) transporter (DAT) in mouse nigrostriatal presynaptic membranes, and its genetic ablation in homozygous null-mutant (GPR37-KO) mice provokes the marked increase of plasma membrane expression of DAT, alteration of psychostimulant-induced locomotor activity, and reduction of catalepsy induced by DA-receptor antagonists. We report that extracts from GPR37-KO mice displayed biochemical alterations of the nigrostriatal signaling pathways mediated by D1 and D2 dopaminergic receptors. Null-mutant mice showed an increase of the basal phosphorylation level of the D2-regulated Akt kinase. The basal phosphorylation of the D1-activated ERK2 kinase was not altered, but acute treatments with amphetamine or cocaine failed to produce its specific increase, as detected in samples from wild-type littermates. Furthermore, the chronic administration of cocaine to GPR37-KO mice did not increase the expression of the Delta FosB transcription factor isoforms. Consistently, behavioral analysis showed that null-mutant animals did not respond to the incentive properties of amphetamine or cocaine, in conditioned place preference tests. Thus, the lack of GPR37 affects both ERK2- and Akt-mediated striatal signaling pathways, impairing the biochemical and behavioral responses typically induced by acute and chronic administration of psychostimulant drugs.-Marazziti, D., Di Pietro, C., Mandillo, S., Golini, E., Matteoni, R., and Tocchini-Valentini, G. P. Absence of the GPR37/PAEL receptor impairs striatal Akt and ERK2 phosphorylation, Delta FosB expression, and conditioned place preference to amphetamine and cocaine. FASEB J. 25, 2071-2081 (2011). www.fasebj.org (literal)

Prodotto di