GPR37 associates with the dopamine transporter to modulate dopamine uptake (Articolo in rivista)

Type
Label
  • GPR37 associates with the dopamine transporter to modulate dopamine uptake (Articolo in rivista) (literal)
Anno
  • 2007-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1073/pnas.0703368104 (literal)
Alternative label
  • Marazziti D; Mandillo S; Di Pietro C; Golini E; Matteoni R; Tocchini-Valentini GP (2007)
    GPR37 associates with the dopamine transporter to modulate dopamine uptake
    in Proceedings of the National Academy of Sciences of the United States of America; National Academy of Sciences, Washington (Stati Uniti d'America)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Marazziti D; Mandillo S; Di Pietro C; Golini E; Matteoni R; Tocchini-Valentini GP (literal)
Pagina inizio
  • 9846 (literal)
Pagina fine
  • 9851 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.pnas.org/content/104/23/9846.long (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 104 (literal)
Rivista
Note
  • Pubme (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • CNR-IBC (literal)
Titolo
  • GPR37 associates with the dopamine transporter to modulate dopamine uptake (literal)
Abstract
  • The orphan G protein-coupled receptor 37 (GPR37) is a substrate of parkin; its insoluble aggregates accumulate in brain samples of Parkinson's disease patients. We report here that GPR37 interacts with the dopamine transporter (DAT) and modulates DAT activity. GPR37 and DAT were found colocalized in mouse striatal presynaptic membranes and in transfected cells and their interaction was confirmed by coimmunoprecipitation assays. Gpr37-null mutant mice showed enhanced DAT-mediated dopamine uptake in striatal membrane samples, with a significant increase in the number of plasma membrane DAT molecules. The null mutant mice also exhibited a decrease in cocaine-induced locomotor activity and in catalepsy induced by dopamine receptor antagonists. These results reveal the specific role of GPR37, a putative peptidergic G protein-coupled receptor, in modulating the functional expression of DAT and the behavioral responses to dopaminergic drugs. (literal)
Editore
Prodotto di
Autore CNR
Insieme di parole chiave

Incoming links:


Autore CNR di
Prodotto
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
Editore di
Insieme di parole chiave di
data.CNR.it