Reduced cumulative incidence of diabetes but not insulitis following administration of chimeric human IL-15-murine IgG2b in NOD mice (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Reduced cumulative incidence of diabetes but not insulitis following administration of chimeric human IL-15-murine IgG2b in NOD mice (Articolo in rivista) (literal)

Anno

• 2003-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1002/dmrr.400 (literal)

Alternative label

• Signore A, Annovazzi A, Giacalone P, Beales PE, Valorani MG, Vestri AR, Ruberti G, Manfrini S, Pozzilli P, Bulfone-Paus S. (2003)
  Reduced cumulative incidence of diabetes but not insulitis following administration of chimeric human IL-15-murine IgG2b in NOD mice
  in Diabetes/metabolism research and reviews (Online)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Signore A, Annovazzi A, Giacalone P, Beales PE, Valorani MG, Vestri AR, Ruberti G, Manfrini S, Pozzilli P, Bulfone-Paus S. (literal)

Pagina inizio

• 464 (literal)

Pagina fine

• 468 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 19 (literal)

Rivista

• Diabetes/metabolism research and reviews (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto

• Pubblicazione su rivista scientifica (literal)

Note

• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• CNR-IBC (literal)

Titolo

• Reduced cumulative incidence of diabetes but not insulitis following administration of chimeric human IL-15-murine IgG2b in NOD mice (literal)

Abstract

• BACKGROUND: It has been recently demonstrated that apoptosis is involved in beta-cell destruction in the NOD mouse model of diabetes. The aim of the present study was to investigate whether IL-15, a cytokine involved in the modulation of the apoptotic process, is capable of modifying the natural history of diabetes and/or insulitis in pre-diabetic NOD mice. The rationale for the use of IL-15-IgG2b recombinant cytokine is related to its long half-life (28 +/- 4 h). METHODS: At 10 weeks of age, 2 groups of 24 female mice were treated with single or multiple i.p. doses of IL-15-IgG2b respectively. As control, 2 groups of 24 age- and litter-matched female mice were injected intra-peritoneally with single or multiple doses of insulitis were observed in all treated and control mice. CONCLUSIONS: We conclude that IL-15-IgG2b reduces the cumulative incidence of diabetes, without affecting the extent and severity of the insulitis process. Considering this and the well-defined anti-apoptotic effects of IL-15, we suggest that the reduction of diabetes incidence could be due to a down-regulation of beta-cell apoptosis. Copyright 2003 John Wiley & Sons, Ltd. (literal)

Prodotto di

• Trasduzione del segnale e malattie multifattoriali (SV.P15.004.001) (Modulo)
• Institute of cell biology (IBC) (Istituto)

Autore CNR

• GIOVINA RUBERTI (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "Reduced cumulative incidence of diabetes but not insulitis following administration of chimeric human IL-15-murine IgG2b in NOD mice" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of cell biology (IBC) (Istituto)
• Trasduzione del segnale e malattie multifattoriali (SV.P15.004.001) (Modulo)

Autore CNR di

• GIOVINA RUBERTI (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Diabetes/metabolism research and reviews (Rivista)

Insieme di parole chiave di

• Parole chiave di "Reduced cumulative incidence of diabetes but not insulitis following administration of chimeric human IL-15-murine IgG2b in NOD mice" (Insieme di parole chiave)