Determination of the structure of the lipid A fraction from the lipopolysaccharide of Pseudomonas cichorii by means of NMR and MALDI-TOF mass spectrometry (Articolo in rivista)

Type
Label
  • Determination of the structure of the lipid A fraction from the lipopolysaccharide of Pseudomonas cichorii by means of NMR and MALDI-TOF mass spectrometry (Articolo in rivista) (literal)
Anno
  • 2002-01-01T00:00:00+01:00 (literal)
Alternative label
  • Molinaro A., Silipo A., Lanzetta R., Parrilli M., Malvagna P., Evidente A., Surico G. (2002)
    Determination of the structure of the lipid A fraction from the lipopolysaccharide of Pseudomonas cichorii by means of NMR and MALDI-TOF mass spectrometry
    in European journal of organic chemistry (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Molinaro A., Silipo A., Lanzetta R., Parrilli M., Malvagna P., Evidente A., Surico G. (literal)
Pagina inizio
  • 3119 (literal)
Pagina fine
  • 3125 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 18 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Titolo
  • Determination of the structure of the lipid A fraction from the lipopolysaccharide of Pseudomonas cichorii by means of NMR and MALDI-TOF mass spectrometry (literal)
Abstract
  • The chemical structure of lipid A from the lipopolysaccharide of the plant- associated bacterium Pseudomonas cichorii, was elucidated by compositional analysis and spectroscopic methods (MALDI-TOF and 2D NMR). The lipid A fraction showed remarkable heterogeneity with respect to the fatty acid and phosphate composition. The major species are hexaacylated and pentaacylated lipid A, bearing the (R)-3-hydroxydodecanoic acid [C12:0 (3OH)] in amide linkage and an (R)-3-hydroxydecanoic [C10:0 (3OH)] in ester linkage while the secondary fatty acids are present as C12:0 and C12:0 (2-OH). A nonstoichiometric phosphate substitution at position C-4' of the distal GlcN was detected. Interestingly, the pentaacyl lipid A is lacking a primary fatty acid, namely the C10:0 (3-OH) at position C-3'. A potential biological meaning of this peculiar lipid A is also suggested. (literal)
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