On the role of conserved moieties in shaping the robustness and production capabilities of reaction networks (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• On the role of conserved moieties in shaping the robustness and production capabilities of reaction networks (Articolo in rivista) (literal)

Anno

• 2009-01-01T00:00:00+01:00 (literal)

Alternative label

• De Martino, A.; Martelli, C.; Massucci, F.A. (2009)
  On the role of conserved moieties in shaping the robustness and production capabilities of reaction networks
  in Europhysics letters (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• De Martino, A.; Martelli, C.; Massucci, F.A. (literal)

Pagina inizio

• 38007 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 85 (literal)

Rivista

• Europhysics letters (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• CNR/INFM (SMC), Dipartimento di Fisica, Sapienza Universita` di Roma - p.le A. Moro 2, 00185 Roma, Italy, EU Dipartimento di Fisica, Sapienza Universita` di Roma - p.le A. Moro 2, 00185 Roma, Italy, EU (literal)

Titolo

• On the role of conserved moieties in shaping the robustness and production capabilities of reaction networks (literal)

Abstract

• We study a simplified, solvable model of a fully connected metabolic network with constrained quenched disorder to mimic the conservation laws imposed by stoichiometry on chemical reactions. Within a spin-glass type of approach, we show that in the presence of a conserved metabolic pool the flux state corresponding to maximal growth is stationary independently of the pool size. In addition, and at odds with the case of unconstrained networks, the volume of optimal flux configurations remains finite, indicating that the frustration imposed by stoichiometric constraints, while reducing growth capabilities, confers robustness and flexibility to the system. These results have a clear biological interpretation and provide a basic, fully analytical explanation to features recently observed in real metabolic networks (literal)

Prodotto di

• Institute for chemical and physical processes (IPCF) (Istituto)
• MD.P01.024.001 Dinamica dei sistemi disordinati: materia soffice e biologica (MD.P01.024.002) (Modulo)

Autore CNR

• ANDREA DE MARTINO (Unità di personale interno)

Incoming links:

Prodotto

• Institute for chemical and physical processes (IPCF) (Istituto)
• MD.P01.024.001 Dinamica dei sistemi disordinati: materia soffice e biologica (MD.P01.024.002) (Modulo)

Autore CNR di

• ANDREA DE MARTINO (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Europhysics letters (Rivista)