In vitro and in vivo MR evaluation of internal gradient to assess trabecular bone density (Articolo in rivista)

Type
Label
  • In vitro and in vivo MR evaluation of internal gradient to assess trabecular bone density (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1088/0031-9155/55/19/010 (literal)
Alternative label
  • De Santis, S.; Rebuzzi, M.; Di Pietro, G.; Fasano, F.; Maraviglia, B.; Capuani, S. (2010)
    In vitro and in vivo MR evaluation of internal gradient to assess trabecular bone density
    in Physics in medicine and biology (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • De Santis, S.; Rebuzzi, M.; Di Pietro, G.; Fasano, F.; Maraviglia, B.; Capuani, S. (literal)
Pagina inizio
  • 5767 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 55 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • CNR-IPCF; Physics Dpt. Sapienza University of Rome (literal)
Titolo
  • In vitro and in vivo MR evaluation of internal gradient to assess trabecular bone density (literal)
Abstract
  • Here we propose a new magnetic resonance (MR) strategy based on the evaluation of internal gradient (G(i)) to assess the trabecular bone (TB) density in spongy bone. Spongy bone is a porous system characterized by a solid trabecular network immersed in bone marrow and characterized by a different relative percentage of water and fats. Using a 9.4 TMR micro-imaging system, we first evaluated the relative water and fat G(i) as extracted from the Spin-Echo decay function in vitro of femoral head samples from calves. Indeed, the differential effects of fat and water diffusion result in different types of G(i) behavior. Using a clinical MR 3T scanner, we then investigated in vivo the calcanei of individuals characterized by different known TB densities. We demonstrate, on these samples, that water is more prevalent in the boundary zone, while fats are rearranged primarily in the central zone of each pore. In vitro experiments showed that water G(i) magnitude from the samples was directly proportional to their TB density. Similar behavior was also observed in the clinical measures. Conversely, fat G(i) did not provide any information on spongy-bone density. Our results suggest that water G(i) may be a reliable marker to assess the status of spongy bone (literal)
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