Force amplification response of actin filaments under confined compression (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Force amplification response of actin filaments under confined compression (Articolo in rivista) (literal)

Anno

• 2009-01-01T00:00:00+01:00 (literal)

Alternative label

• Greene GW, Anderson TH, Zeng H, Zappone B, Israelachvili JN (2009)
  Force amplification response of actin filaments under confined compression
  in Proceedings of the National Academy of Sciences of the United States of America
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Greene GW, Anderson TH, Zeng H, Zappone B, Israelachvili JN (literal)

Pagina inizio

• 445 (literal)

Pagina fine

• 449 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 106 (literal)

Rivista

• Proceedings of the National Academy of Sciences of the United States of America (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• IPCF UOS Cosenza Univ Calif Santa Barbara, Dept Chem Engn, Santa Barbara, CA 93106 USA Univ Calabria, Ctr Eccellenza CEMIF CAL, I-87036 Arcavacata Di Rende, CS Italy (literal)

Titolo

• Force amplification response of actin filaments under confined compression (literal)

Abstract

• Actin protein is a major component of the cell cytoskeleton, and its ability to respond to external forces and generate propulsive forces through the polymerization of filaments is central to many cellular processes. The mechanisms governing actin's abilities are still not fully understood because of the difficulty in observing these processes at a molecular level. Here, we describe a technique for studying actin-surface interactions by using a surface forces apparatus that is able to directly visualize and quantify the collective forces generated when layers of noninterconnected, end-tethered actin filaments are confined between 2 (mica) surfaces. We also identify a force-response mechanism in which filaments not only stiffen under compression, which increases the bending modulus, but more importantly generates opposing forces that are larger than the compressive force. This elastic stiffening mechanism appears to require the presence of confining surfaces, enabling actin filaments to both sense and respond to compressive forces without additional mediating proteins, providing insight into the potential role compressive forces play in many actin and other motor protein-based phenomena. (literal)

Prodotto di

• MD.P01.016.001 Soft Matter e nanotecnologie per elettro-ottica e di interesse biomedico e applicazioni tecnologiche correlate (MD.P01.016.002) (Modulo)
• Institute for chemical and physical processes (IPCF) (Istituto)

Autore CNR

• BRUNO ZAPPONE (Persona)

Incoming links:

Prodotto

• Institute for chemical and physical processes (IPCF) (Istituto)
• MD.P01.016.001 Soft Matter e nanotecnologie per elettro-ottica e di interesse biomedico e applicazioni tecnologiche correlate (MD.P01.016.002) (Modulo)

Autore CNR di

• BRUNO ZAPPONE (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Proceedings of the National Academy of Sciences of the United States of America (Rivista)