Innate difference in the endocannabinoid signaling and its modulation by alcohol consumption in alcohol-preferring sP rats (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Innate difference in the endocannabinoid signaling and its modulation by alcohol consumption in alcohol-preferring sP rats (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1111/j.1369-1600.2010.00299.x (literal)

Alternative label

• Vinod K.Y., Maccioni P., Garcia-Gutierrez M.S., Femenia T., Xie S., Carai M.A.M., Manzanares J., Cooper T.B., Hungund B.L., Colombo G (2012)
  Innate difference in the endocannabinoid signaling and its modulation by alcohol consumption in alcohol-preferring sP rats
  in Addiction biology (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Vinod K.Y., Maccioni P., Garcia-Gutierrez M.S., Femenia T., Xie S., Carai M.A.M., Manzanares J., Cooper T.B., Hungund B.L., Colombo G (literal)

Pagina inizio

• 62 (literal)

Pagina fine

• 75 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 17 (literal)

Rivista

• Addiction biology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 14 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Division of Analytical Psychopharmacology, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA; Department of Adolescent and Child Psychiatry, New York University Langone Medical Center, New York, NY, USA; Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, NY, USA; CNR Neuroscience Institute, Cagliari, Italy;.Instituto de Neurociencias de Alicante, University Miguel Hernandez, Alicante, Spain; Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA (literal)

Titolo

• Innate difference in the endocannabinoid signaling and its modulation by alcohol consumption in alcohol-preferring sP rats (literal)

Abstract

• The present study examined whether genetically predetermined differences in the components of the endocannabinoid system exist in the brain of Sardinian alcohol-preferring (sP) and Sardinian alcohol-non preferring (sNP) rats, a pair of rat lines selectively bred for opposite alcohol preference. The effects of acquisition and maintenance of alcohol drinking, alcohol withdrawal, and alcohol re-exposure on the endocannabinoid system were also investigated in the striatum of sP rats. The findings revealed significantly higher levels of the CB1 receptors, CB1 receptor mRNA, CB1 receptor-mediated G-protein coupling and endocannabinoids in the cerebral cortex, hippocampus and striatum of alcohol-naive sP rats than sNP rats. A significantly lower expression of mFAAH enzyme was evident in the hippocampus of alcohol-naive sP rats. Alcohol drinking (during both acquisition and maintenance phases) in sP rats resulted in a significant reduction in the striatal CB1 receptor-mediated G-protein coupling whereas alcohol withdrawal attenuated this effect. Alcohol consumption was also associated with marked elevation in the endocannabinoids in the striatum. Co-administration of the CB1 receptor antagonist, rimonabant (SR141716A), reduced alcohol drinking, and reversed alcohol-induced changes in the CB1 receptor-mediated G-protein coupling. These findings provided a new insight into a genetic basis of excessive alcohol consumption, suggesting innate differences in the endocannabinoid system may be associated with higher alcohol preference in sP rats. The data also indicate modulation of the CB1 receptor-mediated signaling by alcohol consumption and further strengthen the hypothesis that the endocannabinoid system could be a target for the treatment of alcohol related behaviors. (literal)

Prodotto di

• Neurobiologia dell'alcolismo (ME.P02.020.001) (Modulo)
• Istituto di neuroscienze (IN) (Istituto)

Autore CNR

• MAURO ANTONIO MARIA CARAI (Unità di personale esterno)
• PAOLA MACCIONI (Unità di personale esterno)
• GIANCARLO COLOMBO (Unità di personale interno)

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• Parole chiave di "Innate difference in the endocannabinoid signaling and its modulation by alcohol consumption in alcohol-preferring sP rats" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• GIANCARLO COLOMBO (Unità di personale interno)
• MAURO ANTONIO MARIA CARAI (Unità di personale esterno)
• PAOLA MACCIONI (Unità di personale esterno)

Prodotto

• Istituto di neuroscienze (IN) (Istituto)
• Neurobiologia dell'alcolismo (ME.P02.020.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Addiction biology (Rivista)

Insieme di parole chiave di

• Parole chiave di "Innate difference in the endocannabinoid signaling and its modulation by alcohol consumption in alcohol-preferring sP rats" (Insieme di parole chiave)