Inactivation kinetics of voltage-gated calcium channels in glutamatergic neurons are influenced by SNAP-25. (Articolo in rivista)

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  • Inactivation kinetics of voltage-gated calcium channels in glutamatergic neurons are influenced by SNAP-25. (Articolo in rivista) (literal)
Anno
  • 2011-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.4161/chan.5.4.16228 (literal)
Alternative label
  • Condliffe SB1, and Matteoli M2 (2011)
    Inactivation kinetics of voltage-gated calcium channels in glutamatergic neurons are influenced by SNAP-25.
    in Channels (Austin Tex.)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Condliffe SB1, and Matteoli M2 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 5 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1Department of Physiology; University of Otago; Dunedin, New Zealand; 2Department of Medical Pharmacology; CNR Institute of Neuroscience and IRCCS Don Gnocchi; University of Milano; Milano, Italy (literal)
Titolo
  • Inactivation kinetics of voltage-gated calcium channels in glutamatergic neurons are influenced by SNAP-25. (literal)
Abstract
  • SNAP-25 forms part of the SNARE core complex that mediates membrane fusion. Biochemical and electrophysiological evidence supports an accessory role for SNAP-25 in interacting with voltage-gated calcium channels (VGCCs) to modulate channel activity. We recently reported that endogenous SNAP-25 negatively regulates VGCC activity in glutamatergic neurons from rat hippocampal cultures by shifting the voltage-dependence of inactivation of the predominant P/Q-type channel current in these cells. In the present study, we extend these findings by investigating the effect that manipulating endogenous SNAP-25 expression has on the inactivation kinetics of VGCC current in both glutamatergic and GABAergic cells recorded from 9-13 DIV cultures. Silencing SNAP-25 in glutamatergic neurons significantly slowed the inactivation rate of P/Q-type VGCC current whereas alterations in SNAP-25 expression did not alter inactivation rates in GABAergic neurons. These results indicate that endogenous SNAP-25 plays an important role in P/Q-type channel regulation in glutamatergic neurons. (literal)
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