Lack of dystrophin functionally affects alpha 3 beta 2/beta 4-nicotinic acethylcholine receptors in sympathetic neurons of dystrophic mdx mice (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Lack of dystrophin functionally affects alpha 3 beta 2/beta 4-nicotinic acethylcholine receptors in sympathetic neurons of dystrophic mdx mice (Articolo in rivista) (literal)

Anno

• 2011-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.nbd.2010.10.024 (literal)

Alternative label

• Di Angelantonio, Silvia; De Stefano, Maria Egle; Piccioni, Alessio; Lombardi, Loredana; Gotti, Cecilia; Paggi, Paola (2011)
  Lack of dystrophin functionally affects alpha 3 beta 2/beta 4-nicotinic acethylcholine receptors in sympathetic neurons of dystrophic mdx mice
  in Neurobiology of disease
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Di Angelantonio, Silvia; De Stefano, Maria Egle; Piccioni, Alessio; Lombardi, Loredana; Gotti, Cecilia; Paggi, Paola (literal)

Pagina inizio

• 528 (literal)

Pagina fine

• 537 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 41 (literal)

Rivista

• Neurobiology of disease (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 10 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 2 (literal)

Note

• ISI Web of Science (WoS) (literal)
• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Sapienza University Rome; Sapienza University Rome; Sapienza University Rome; University of Milan; Consiglio Nazionale delle Ricerche (CNR) (literal)

Titolo

• Lack of dystrophin functionally affects alpha 3 beta 2/beta 4-nicotinic acethylcholine receptors in sympathetic neurons of dystrophic mdx mice (literal)

Abstract

• In the sympathetic superior cervical ganglion (SCG), nicotinic acetylcholine receptors (nAChRs) mediate fast synaptic transmission. We previously demonstrated that in SCG neurons of mdx mice, an animal model for Duchenne muscular dystrophy, lack of dystrophin causes a decrease, compared to the wild-type, in postsynaptic nAChRs containing the alpha 3 subunit associated with beta 2 and/or beta 4 (alpha 3 beta 2/beta 4-nAChRs), but not in those containing the alpha 7 subunit. Here we show, by whole cell patch-clamp recordings from cultured SCG neurons, that both nicotine and acetylcholine-evoked currents through alpha 3 beta 2/beta 4-nAChRs are significantly reduced in mdx mice compared to the wild-type, while those through ea-nAChR are unaffected. This reduction associates with that of protein levels of alpha 3, beta 2 and beta 4 subunits. Therefore, we suggest that, in mdx mouse SCG neurons, lack of dystrophin, by specifically affecting membrane stabilization of alpha 3 beta 2/beta 4-nAChRs, could determine an increase in receptor internalization and degradation, with consequent reduction in the fast intraganglionic cholinergic transmission. (c) 2010 Elsevier Inc. All rights reserved, (literal)

Prodotto di

• Istituto di neuroscienze (IN) (Istituto)
• Farmacologia Cellulare e Molecolare delle Cellule Nervose (ME.P02.007.001) (Modulo)

Autore CNR

• CECILIA GOTTI (Persona)

Insieme di parole chiave

• Keywords of "Lack of dystrophin functionally affects alpha 3 beta 2/beta 4-nicotinic acethylcholine receptors in sympathetic neurons of dystrophic mdx mice" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di neuroscienze (IN) (Istituto)
• Farmacologia Cellulare e Molecolare delle Cellule Nervose (ME.P02.007.001) (Modulo)

Autore CNR di

• CECILIA GOTTI (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Neurobiology of disease (Rivista)

Insieme di parole chiave di

• Keywords of "Lack of dystrophin functionally affects alpha 3 beta 2/beta 4-nicotinic acethylcholine receptors in sympathetic neurons of dystrophic mdx mice" (Insieme di parole chiave)