Evidence for sub-haplogroup h5 of mitochondrial DNA as a risk factor for late onset Alzheimer's disease. (Articolo in rivista)

Type
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  • Evidence for sub-haplogroup h5 of mitochondrial DNA as a risk factor for late onset Alzheimer's disease. (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Alternative label
  • Santoro A; Balbi V; Balducci E; Pirazzini C; Rosini F; Tavano F; Achilli A; Siviero P; Minicuci N; Bellavista E; Mishto M; Salvioli S; Marchegiani F; Cardelli M; Olivieri F; Nacmias B; Chiamenti AM; Benussi L; Ghidoni R; Rose G; Gabelli C; Binetti G; et al. (2010)
    Evidence for sub-haplogroup h5 of mitochondrial DNA as a risk factor for late onset Alzheimer's disease.
    in PloS one
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Santoro A; Balbi V; Balducci E; Pirazzini C; Rosini F; Tavano F; Achilli A; Siviero P; Minicuci N; Bellavista E; Mishto M; Salvioli S; Marchegiani F; Cardelli M; Olivieri F; Nacmias B; Chiamenti AM; Benussi L; Ghidoni R; Rose G; Gabelli C; Binetti G; et al. (literal)
Pagina inizio
  • 12037 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 5 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Department of Experimental Pathology, University of Bologna, Bologna, Italy, CIG-Interdepartmental Center for Biophysics and Biocomplexity Studies, University of Bologna, Bologna, Italy, Department of Genetics and Microbiology, University of Pavia, Pavia, Italy, Department of Cell and Environmental Biology, University of Perugia, Perugia, Italy, National Council Research, Institute of Neuroscience, Padova, Italy, Institute of Biochemistry, Medical Faculty Charite´ , Berlin, Germany, Italian National Research Center for Aging (I.N.R.C.A.), Ancona, Italy, Department of Molecular Pathology and Innovative Therapies, Polytechnic University of Marche, Ancona, Italy, Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy, Regional Center for Cerebral Aging, Valdagno, Vicenza, Italy, NeuroBioGen Lab-Memory Clinic, ''Centro S.Giovanni di Dio-Fatebenefratelli'', Brescia, Italy, 12 Proteomics Unit, ''Centro S.Giovanni di Dio-Fatebenefratelli'', Brescia, Italy, Department of Cell Biology, University of Calabria, Rende, Cosenza, Italy (literal)
Titolo
  • Evidence for sub-haplogroup h5 of mitochondrial DNA as a risk factor for late onset Alzheimer's disease. (literal)
Abstract
  • Background: Alzheimer's Disease (AD) is the most common neurodegenerative disease and the leading cause of dementia among senile subjects. It has been proposed that AD can be caused by defects in mitochondrial oxidative phosphorylation. Given the fundamental contribution of the mitochondrial genome (mtDNA) for the respiratory chain, there have been a number of studies investigating the association between mtDNA inherited variants and multifactorial diseases, however no general consensus has been reached yet on the correlation between mtDNA haplogroups and AD. Methodology/Principal Findings: We applied for the first time a high resolution analysis (sequencing of displacement loop and restriction analysis of specific markers in the coding region of mtDNA) to investigate the possible association between mtDNA-inherited sequence variation and AD in 936 AD patients and 776 cognitively assessed normal controls from central and northern Italy. Among over 40 mtDNA sub-haplogroups analysed, we found that sub-haplogroup H5 is a risk factor for AD (OR = 1.85, 95% CI:1.04-3.23) in particular for females (OR = 2.19, 95% CI:1.06-4.51) and independently from the APOE genotype. Multivariate logistic regression revealed an interaction between H5 and age. When the whole sample is considered, the H5a subgroup of molecules, harboring the 4336 transition in the tRNAGln gene, already associated to AD in early studies, was about threefold more represented in AD patients than in controls (2.0% vs 0.8%; p = 0.031), and it might account for the increased frequency of H5 in AD patients (4.2% vs 2.3%). The complete re-sequencing of the 56 mtDNAs belonging to H5 revealed that AD patients showed a trend towards a higher number (p = 0.052) of sporadic mutations in tRNA and rRNA genes when compared with controls. Conclusions: Our results indicate that high resolution analysis of inherited mtDNA sequence variation can help in identifying both ancient polymorphisms defining sub-haplogroups and the accumulation of sporadic mutations associated with complex traits such as AD. (literal)
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