An investigation of the occurrence and properties of the mitochondrial intermediate-conductance Ca2+-activated K+ channel mtKCa3.1. (Articolo in rivista)

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  • An investigation of the occurrence and properties of the mitochondrial intermediate-conductance Ca2+-activated K+ channel mtKCa3.1. (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.bbabio.2009.12.015 (literal)
Alternative label
  • Sassi N; U. De Marchi; B. Fioretti; L. Biasutto; E. Gulbins; F. Franciolini; I. Szabò; M. Zoratti (2010)
    An investigation of the occurrence and properties of the mitochondrial intermediate-conductance Ca2+-activated K+ channel mtKCa3.1.
    in Biochimica et biophysica acta. Bioenergetics
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Sassi N; U. De Marchi; B. Fioretti; L. Biasutto; E. Gulbins; F. Franciolini; I. Szabò; M. Zoratti (literal)
Pagina inizio
  • 1260 (literal)
Pagina fine
  • 1267 (literal)
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  • http://www.sciencedirect.com/science/article/pii/S0005272809003107 (literal)
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  • 1797 (literal)
Rivista
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  • 8 (literal)
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  • 6-7 (literal)
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  • Scopu (literal)
  • ISI Web of Science (WOS) (literal)
  • PubMe (literal)
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  • Sassi N; De Marchi U; Biasutto L; Zoratti M: Dipartimento di Scienze Biomediche Sperimentali, Università di Padova. Fioretti B; Franciolini F: Dipartimento di Biologia Cellulare ed Ambientale, Università di Perugia. Gulbins E: Department of Molecular Biology, University of Duisburg-Essen, Germany. Szabò I: Dipartimento di Biologia, Università di Padova. Zoratti M: IN - Padova (literal)
Titolo
  • An investigation of the occurrence and properties of the mitochondrial intermediate-conductance Ca2+-activated K+ channel mtKCa3.1. (literal)
Abstract
  • The mitochondrial intermediate-conductance Ca2+-activated K+ channel mtKCa3.1 has recently been discovered in the HCT116 colon tumor-derived cell line, which expresses relatively high levels of this protein also in the plasma membrane. Electrophysiological recordings revealed that the channel can exhibit different conductance states and kinetic modes, which we tentatively ascribe to post-translational modifications. To verify whether the localization of this channel in mitochondria might be a peculiarity of these cells or a more widespread feature we have checked for the presence of mtKCa3.1 in a few other cell lines using biochemical and electrophysiological approaches. It turned out to be present at least in some of the cells investigated. Functional assays explored the possibility that mtKCa3.1 might be involved in cell proliferation or play a role similar to that of the Shaker-type KV1.3 channel in lymphocytes, which interacts with outer mitochondrial membrane-inserted Bax thereby promoting apoptosis (Szabò, I. et al., Proc. Natl. Acad Sci. USA 105 (2008) 14861-14866). A specific KCa3.1 inhibitor however did not have any detectable effect on cell proliferation or death. (literal)
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