Regioselective O-derivatization of quercetin via ester intermediates. An improved synthesis of rhamnetin and development of a new mitochondriotropic derivative. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Regioselective O-derivatization of quercetin via ester intermediates. An improved synthesis of rhamnetin and development of a new mitochondriotropic derivative. (Articolo in rivista) (literal)

Anno

• 2010-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.3390/molecules15074722 (literal)

Alternative label

• Mattarei A; L. Biasutto; F. Rastrelli; S. Garbisa; E. Marotta; M. Zoratti; C. Paradisi. (2010)
  Regioselective O-derivatization of quercetin via ester intermediates. An improved synthesis of rhamnetin and development of a new mitochondriotropic derivative.
  in Molecules (Basel, Online)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Mattarei A; L. Biasutto; F. Rastrelli; S. Garbisa; E. Marotta; M. Zoratti; C. Paradisi. (literal)

Pagina inizio

• 4722 (literal)

Pagina fine

• 4736 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 15 (literal)

Rivista

• Molecules (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 15 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 7 (literal)

Note

• PubMe (literal)
• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Mattarei A; Rastrelli F; Marotta E; Paradisi C: Dip. di Scienze Chimiche, Università di Padova. Biasutto L; Garbisa S; Zoratti M: Dip. di Scienze Biomediche Sperimentali, Università di Padova. Zoratti M: IN - Padova (literal)

Titolo

• Regioselective O-derivatization of quercetin via ester intermediates. An improved synthesis of rhamnetin and development of a new mitochondriotropic derivative. (literal)

Abstract

• The regioselective synthesis of several quercetin (3,3',4',5,7-pentahydroxy flavone) tetraesters bearing a single free OH on 5-C was achieved in good yield by proper choice of reaction conditions using common esterification procedures. Tetracetylated quercetin with the free OH on 7-C was selectively obtained instead via imidazole-promoted deacylation of the corresponding pentaester. Unambiguous structural characterization of the two isomeric tetraacetyl quercetin derivatives was obtained by combined HSQC and HMBC 2D-NMR analysis. These molecules can be used as starting materials for the regioselective synthesis of other derivatives. High yield syntheses of the natural polyphenol rhamnetin (7-O-methylquercetin) and of the new mitochondriotropic compound 7-(4-triphenylphosphoniumbutyl) quercetin iodide are reported as examples. (literal)

Prodotto di

• Istituto di neuroscienze (IN) (Istituto)
• Neurobiologia e Neuropatologia (ME.P02.005.001) (Modulo)

Autore CNR

• LUCIA BIASUTTO (Unità di personale interno)
• MARIO ZORATTI (Persona)

Insieme di parole chiave

• Parole chiave di "Regioselective O-derivatization of quercetin via ester intermediates. An improved synthesis of rhamnetin and development of a new mitochondriotropic derivative." (Insieme di parole chiave)

Incoming links:

Autore CNR di

• MARIO ZORATTI (Persona)
• LUCIA BIASUTTO (Unità di personale interno)

Prodotto

• Istituto di neuroscienze (IN) (Istituto)
• Neurobiologia e Neuropatologia (ME.P02.005.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Molecules (Rivista)

Insieme di parole chiave di

• Parole chiave di "Regioselective O-derivatization of quercetin via ester intermediates. An improved synthesis of rhamnetin and development of a new mitochondriotropic derivative." (Insieme di parole chiave)