Synaptic activity controls dendritic spine morphology by modulating eEF2-dependent BDNF synthesis. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Synaptic activity controls dendritic spine morphology by modulating eEF2-dependent BDNF synthesis. (Articolo in rivista) (literal)

Anno

• 2010-01-01T00:00:00+01:00 (literal)

Alternative label

• Verpelli C, Piccoli G, Zanchi A, Gardoni F, Huang K, Brambilla D, Di Luca M, Battaglioli E and Sala C (2010)
  Synaptic activity controls dendritic spine morphology by modulating eEF2-dependent BDNF synthesis.
  in The Journal of neuroscience
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Verpelli C, Piccoli G, Zanchi A, Gardoni F, Huang K, Brambilla D, Di Luca M, Battaglioli E and Sala C (literal)

Pagina inizio

• 5830 (literal)

Pagina fine

• 5842 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 30 (literal)

Rivista

• ?The ?Journal of neuroscience (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1Consiglio Nazionale delle Ricerche Neuroscience Institute and Department of Pharmacology, 2Neurosurgery, Department of Neurological Sciences, 3Department of Biology and Genetics for Medical Sciences, 4Department of Pharmacological Sciences and Centre of Excellence for Neurodegenerative Diseases, and 5Department of Human Physiology, University of Milan, 20122 Milan, Italy, 6Department of Psychiatry, University of British Columbia, Vancouver, British Columbia V6T 2A1, Canada, and 7Neuromuscular Diseases and Neuroimmunology, Neurological Institute Foundation \"Carlo Besta,\" 20133 Milan, Italy (literal)

Titolo

• Synaptic activity controls dendritic spine morphology by modulating eEF2-dependent BDNF synthesis. (literal)

Abstract

• Activity-dependent changes in synaptic structure and spine morphology are required for learning and memory, and depend on protein translation. We show that the kinase for eukaryotic elongation factor 2 (eEF2K) regulates dendritic spine stability and synaptic structure by modulating activity-dependent dendritic BDNF synthesis. Specifically RNAi knockdown of eEF2K reduces dendritic spine stability and inhibits dendritic BDNF protein expression; whereas overexpression of a constitutively activated eEF2K induces spine maturation and increases expression of dendritic BDNF. Furthermore,BDNFoverexpression rescues the spine stability reduced by RNAi knockdown of eEF2K. We also show that synaptic activity-dependent spine maturation and dendritic BDNF protein expression depend on mGluR/ EF2K-induced eEF2 phosphorylation.Wepropose that the eEF2K/eEF2 pathway is a key biochemical sensor that couple neuronal activity to spine plasticity, by controlling the dendritic translation of BDNF. (literal)

Prodotto di

• Istituto di neuroscienze (IN) (Istituto)
• Farmacologia Cellulare e Molecolare delle Cellule Nervose (ME.P02.007.001) (Modulo)

Autore CNR

• CHIARA VERPELLI (Unità di personale interno)
• CARLO SALA (Unità di personale interno)
• GIOVANNI PICCOLI (Persona)

Incoming links:

Autore CNR di

• CARLO SALA (Unità di personale interno)
• CHIARA VERPELLI (Unità di personale interno)
• GIOVANNI PICCOLI (Persona)

Prodotto

• Istituto di neuroscienze (IN) (Istituto)
• Farmacologia Cellulare e Molecolare delle Cellule Nervose (ME.P02.007.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• ?The ?Journal of neuroscience (Rivista)