Intrinsic calcium dynamics control botulinum toxin A susceptibility in distinct neuronal populations. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Intrinsic calcium dynamics control botulinum toxin A susceptibility in distinct neuronal populations. (Articolo in rivista) (literal)

Anno

• 2010-01-01T00:00:00+01:00 (literal)

Alternative label

• Grumelli C, Corradini I, Matteoli M and Verderio C (2010)
  Intrinsic calcium dynamics control botulinum toxin A susceptibility in distinct neuronal populations.
  in Cell calcium (Edinburgh)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Grumelli C, Corradini I, Matteoli M and Verderio C (literal)

Pagina inizio

• 419 (literal)

Pagina fine

• 424 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 47 (literal)

Rivista

• Cell calcium (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1. Univ Milan, Dept Med Pharmacol, I-20129 Milan, Italy 2. Univ Milan, CNR, Inst Neurosci, I-20129 Milan, Italy 3. IRCCS Fdn Don Gnocchi, Milan, Italy (literal)

Titolo

• Intrinsic calcium dynamics control botulinum toxin A susceptibility in distinct neuronal populations. (literal)

Abstract

• SNAP-25 is a SNARE protein implicated in exocytosis and in the negative modulation of voltage-gated calcium channels. We have previously shown that GABAergic synapses, which express SNAP-25 at much lower levels relative to glutamatergic ones, are characterized by a higher calcium responsiveness to depolarization and are largely resistant to botulinum toxin A. We show here that silencing of SNAP-25 in glutamatergic neurons, a procedure which increases Ka-induced calcium elevations, confers these synapses with toxin resistance. Since it is known that calcium reverts the efficacy of botulinum A, we investigated whether the lower effectiveness of the toxin in inhibiting GABAergic vesicle cycling might be attributable to higher evoked calcium transients of inhibitory neurons. We demonstrate that either expression of SNAP-25(1-197) or BAPTA/AM treatment, both inhibiting calcium dynamics, facilitate block of GABAergic vesicle exocytosis upon toxin treatment. These data indicate that intrinsic calcium dynamics control botulinum A susceptibility in distinct neuronal populations. (C) 2010 Elsevier Ltd. All rights reserved. (literal)

Prodotto di

• Istituto di neuroscienze (IN) (Istituto)
• Farmacologia Cellulare e Molecolare delle Cellule Nervose (ME.P02.007.001) (Modulo)

Autore CNR

• CLAUDIA VERDERIO (Unità di personale interno)
• MICHELA MATTEOLI (Persona)

Incoming links:

Prodotto

• Istituto di neuroscienze (IN) (Istituto)
• Farmacologia Cellulare e Molecolare delle Cellule Nervose (ME.P02.007.001) (Modulo)

Autore CNR di

• CLAUDIA VERDERIO (Unità di personale interno)
• MICHELA MATTEOLI (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Cell calcium (Rivista)