Novel channels of the inner mitochondrial membrane (Articolo in rivista)

Type
Label
  • Novel channels of the inner mitochondrial membrane (Articolo in rivista) (literal)
Anno
  • 2009-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.bbabio.2008.11.015 (literal)
Alternative label
  • Zoratti M.; De Marchi U.; Gulbins E.; Szabò I. (2009)
    Novel channels of the inner mitochondrial membrane
    in Biochimica et biophysica acta. Bioenergetics
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Zoratti M.; De Marchi U.; Gulbins E.; Szabò I. (literal)
Pagina inizio
  • 351 (literal)
Pagina fine
  • 363 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.sciencedirect.com/science/article/pii/S0005272808007329 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 1787 (literal)
Rivista
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  • 13 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 5 (literal)
Note
  • Scopu (literal)
  • ISI Web of Science (WOS) (literal)
  • PubMe (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Zoratti M: CNR Institute of Neuroscience, Padova, Italy / Zoratti M; De Marchi U: Department of Biomedical Sciences, University of Padova, Italy / Gulbins E: Dept. of Molecular Biology, University of Duisburg-Essen, Germany. Szabò I: Department of Biology, University of Padova, Italy (literal)
Titolo
  • Novel channels of the inner mitochondrial membrane (literal)
Abstract
  • Along with a large number of carriers, exchangers and \"pumps\", the inner mitochondrial membrane contains ion-conducting channels which endow it with controlled permeability to small ions. Some have been shown to be the mitochondrial counterpart of channels present also in other cellular membranes. The manuscript summarizes the current state of knowledge on the major inner mitochondrial membrane channels, properties, identity and proposed functions. Considerable attention is currently being devoted to two K(+)-selective channels, mtK(ATP) and mtBK(Ca). Their activation in \"preconditioning\" is considered by many to underlie the protection of myocytes and other cells against subsequent ischemic damage. We have recently shown that in apoptotic lymphocytes inner membrane mtK(V)1.3 interacts with the pro-apoptotic protein Bax after the latter has inserted into the outer mitochondrial membrane. Whether the just-discovered mtIK(Ca) has similar cellular role(s) remains to be seen. The Ca(2+) \"uniporter\" has been characterized electrophysiologically, but still awaits a molecular identity. Chloride-selective channels are represented by the 107 pS channel, the first mitochondrial channel to be observed by patch-clamp, and by a approximately 400 pS pore we have recently been able to fully characterize in the inner membrane of mitochondria isolated from a colon tumour cell line. This we propose to represent a component of the Permeability Transition Pore. The available data exclude the previous tentative identification with porin, and indicate that it coincides instead with the still molecularly unidentified \"maxi\" chloride channel. (literal)
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