Intrahippocampal infusion of botulinum neurotoxin E (BoNT/E) reduces spontaneous recurrent seizures in a mouse model of mesial temporal lobe epilepsy (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Intrahippocampal infusion of botulinum neurotoxin E (BoNT/E) reduces spontaneous recurrent seizures in a mouse model of mesial temporal lobe epilepsy (Articolo in rivista) (literal)

Anno

• 2009-01-01T00:00:00+01:00 (literal)

Alternative label

• Antonucci F, Bozzi Y, Caleo M. (2009)
  Intrahippocampal infusion of botulinum neurotoxin E (BoNT/E) reduces spontaneous recurrent seizures in a mouse model of mesial temporal lobe epilepsy
  in Epilepsia (Cph.)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Antonucci F, Bozzi Y, Caleo M. (literal)

Pagina inizio

• 963 (literal)

Pagina fine

• 966 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 50 (literal)

Rivista

• Epilepsia (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• IN.CNR Pisa (literal)

Titolo

• Intrahippocampal infusion of botulinum neurotoxin E (BoNT/E) reduces spontaneous recurrent seizures in a mouse model of mesial temporal lobe epilepsy (literal)

Abstract

• Mesial temporal lobe epilepsy (MTLE) is one of the most common forms of human epilepsy, and it is often resistant to conventional antiepileptic drug (AED) therapy. Here we tested whether a single intrahippocampal administration of the synaptic blocker botulinum neurotoxin E (BoNT/E) is effective in reducing spontaneous recurrent seizures (SRS) in a mouse model of MTLE. Unilateral intrahippocampal injection of kainic acid (KA) in mice was used as a model of MTLE. Electroencephalography (EEG) recordings of SRS were performed during the chronic phase of epilepsy, before and after administration of either BoNT/E or vehicle. Frequency of SRS was significantly decreased for at least 5 days following BoNT/E, but not vehicle, infusion. Our findings demonstrate that BoNT/E can effectively reduce seizure incidence in a mouse model of MTLE. (literal)

Prodotto di

• Istituto di neuroscienze (IN) (Istituto)
• Plasticità e invecchiamento del sistema nervoso (ME.P02.006.001) (Modulo)

Autore CNR

• MATTEO CALEO (Unità di personale interno)
• YURI BOZZI (Persona)
• FLAVIA ANTONUCCI (Unità di personale esterno)

Incoming links:

Autore CNR di

• MATTEO CALEO (Unità di personale interno)
• YURI BOZZI (Persona)
• FLAVIA ANTONUCCI (Unità di personale esterno)

Prodotto

• Istituto di neuroscienze (IN) (Istituto)
• Plasticità e invecchiamento del sistema nervoso (ME.P02.006.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Epilepsia (Rivista)