Development of mitochondrial-targeted derivatives o resveratrol. (Articolo in rivista)

Type
Label
  • Development of mitochondrial-targeted derivatives o resveratrol. (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.bmcl.2008.08.100 (literal)
Alternative label
  • Biasutto L.; Mattarei A.; Marotta E.; Bradaschia A.; Sassi N.; Garbisa S.; Zoratti M.; Paradisi C. (2008)
    Development of mitochondrial-targeted derivatives o resveratrol.
    in Bioorganic & medicinal chemistry letters (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Biasutto L.; Mattarei A.; Marotta E.; Bradaschia A.; Sassi N.; Garbisa S.; Zoratti M.; Paradisi C. (literal)
Pagina inizio
  • 5594 (literal)
Pagina fine
  • 5597 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.sciencedirect.com/science/article/pii/S0960894X08010329 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 18 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 4 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 20 (literal)
Note
  • ISI Web of Science (WOS) (literal)
  • PubMe (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Department of Chemical Sciences, Università di Padova, via Marzolo 1, 35131 Padova, Italy / Department of Biomedical Sciences, Università di Padova, viale G. Colombo 3, 35131 Padova, Italy / CNR Institute of Neuroscience, viale G. Colombo 3, 35131 Padova, Italy (literal)
Titolo
  • Development of mitochondrial-targeted derivatives o resveratrol. (literal)
Abstract
  • To target natural polyphenols to the subcellular site where their redox properties might be exploited at best, that is, mitochondria, we have synthesised new proof-of-principle derivatives by linking resveratrol (3,4',5-trihydroxy-trans-stilbene) to the membrane-permeable lipophilic triphenylphosphonium cation. The new compounds, (4-triphenylphosphoniumbutyl)-4'-O-resveratrol iodide and its bis-acetylated derivative, the latter intended to provide transient protection against metabolic conjugation, accumulate into energized mitochondria as expected and are cytotoxic for fast-growing but not for slower-growing cells. They provide a powerful potential tool to intervene on mitochondrial and cellular redox processes of pathophysiological relevance. (literal)
Prodotto di
Autore CNR
Insieme di parole chiave

Incoming links:


Autore CNR di
Prodotto
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
Insieme di parole chiave di
data.CNR.it