Src-Tyrosine kinases are major agents in mitochondrial tyrosine phosphorylation. (Articolo in rivista)

Type
Label
  • Src-Tyrosine kinases are major agents in mitochondrial tyrosine phosphorylation. (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1002/jcb.21670 (literal)
Alternative label
  • Elena Tibaldi 1; Anna Maria Brunati1; Maria Lina Massimino 2; Annarita Stringaro 3; Marisa Colone 3; Enzo Agostinelli 4; Giuseppe Arancia 3; and Antonio Toninello1*. (2008)
    Src-Tyrosine kinases are major agents in mitochondrial tyrosine phosphorylation.
    in Journal of cellular biochemistry (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Elena Tibaldi 1; Anna Maria Brunati1; Maria Lina Massimino 2; Annarita Stringaro 3; Marisa Colone 3; Enzo Agostinelli 4; Giuseppe Arancia 3; and Antonio Toninello1*. (literal)
Pagina inizio
  • 347 (literal)
Pagina fine
  • 359 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 1783 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1Dipartimento di Chimica Biologica, Universita' di Padova, Istituto di Neuroscienze del C.N.R., Via G. Colombo 3, 35121 Padova, Italy 2Istituto di Neuroscienze del C.N.R., Via G. Colombo 3, 35121 Padova, Italy 3Dipartimento di Tecnologie e Salute, Istituto Superiore di Sanita`, Viale Regina Elena 299, 00161 Roma, Italy 4Dipartimento di Scienze Biochimiche 'A. Rossi Fanelli' and Centro di Biologia Molecolare del C.N.R., Universita di Roma 'La Sapienza', P.le A. Moro, 5, 00185 Roma, Italy (literal)
Titolo
  • Src-Tyrosine kinases are major agents in mitochondrial tyrosine phosphorylation. (literal)
Abstract
  • Mitochondrial tyrosine phosphorylation is emerging as an important mechanism in regulating mitochondrial function. This article, aimed at identifying which kinases are the major agents in mitochondrial tyrosine phosphorylation, shows that this role should be attributed to Src family members. Indeed, various members of this family, for example, Fgr, Fyn, Lyn, c-Src, are constitutively present in the internal structure of mitochondria as well as Csk, a key enzyme in the regulation of the activity of this family. By means of different approaches, biochemical fractioning, Western blotting and immunogold analysis \"in Situ\" of phosphotyrosine signaling, evidence is reported on the existence of a signal transduction pathway from plasma membrane to mitochondria, resulting in increasing Src-dependent mitochondrial tyrosine phosphorylation. The activation of Src kinases at mitochondrial level is associated with the proliferative status where several mitochondrial proteins are specifically tyrosine-phosphorylated. (literal)
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