http://www.cnr.it/ontology/cnr/individuo/prodotto/ID38426

Cellular distribution of Hsp70 expression in rat skeletal muscle. Effects of moderate exercise training and chronica hypoxia. (Articolo in rivista)

Type

Articolo in rivista (Classe)
Prodotto della ricerca (Classe)

Label

Cellular distribution of Hsp70 expression in rat skeletal muscle. Effects of moderate exercise training and chronica hypoxia. (Articolo in rivista) (literal)

Anno

2008-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1007/s12192-008-0048-y (literal)

Alternative label

Tarricone E, Scapin C, Vitadello M, Esposito F, Margonato V, Milano G, Samaja M, Gorza L. (2008)
Cellular distribution of Hsp70 expression in rat skeletal muscle. Effects of moderate exercise training and chronica hypoxia.
in Cell stress & chaperones; Springer, New York (Stati Uniti d'America)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Tarricone E, Scapin C, Vitadello M, Esposito F, Margonato V, Milano G, Samaja M, Gorza L. (literal)

Pagina inizio

483 (literal)

Pagina fine

495 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

http://www.springer.com/biomed/journal/12192 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

13 (literal)

Rivista

Cell stress & chaperones (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

13 (literal)

Note

ISI Web of Science (WOS) (literal)
PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

Department of Biomedical Sciences, University of Padova, Institute of Physical Exercise, Health and Sport Activities, University of Milan, Center of Sport Medicine, Don Gnocchi Foundation, Milan, Department of Medicine, Surgery and Dentistry, University of Milan, Italy, Cardiovascular Surgery, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland (literal)

Titolo

Cellular distribution of Hsp70 expression in rat skeletal muscle. Effects of moderate exercise training and chronica hypoxia. (literal)

Abstract

Rat hindlimb muscles constitutively express the inducible heat shock protein 72 (Hsp70), apparently in proportion to the slow myosin content. Since it remains controversial whether chronic Hsp70 expression reflects the overimposed stress, we investigated Hsp70 cellular distribution in fast muscles of the posterior rat hindlimb after (1) mild exercise training (up to 30 m/min treadmill run for 1 h/day), which induces a remodeling in fast fiber composition, or (2) prolonged exposure to normobaric hypoxia (10%O(2)), which does not affect fiber-type composition. Both conditions increased significantly protein Hsp70 levels in the skeletal muscle. Immunohistochemistry showed the labeling for Hsp70 in subsets of both slow/type 1 and fast/type 2A myofibers of control, sedentary, and normoxic rats. Endurance training increased about threefold the percentage of Hsp70-positive myofibers (P < 0.001), and changed the distribution of Hsp70 immunoreactivity, which involved a larger subset of both type 2A and intermediate type 2A/2X myofibers (P < 0.001) and vascular smooth muscle cells. Hypoxia induced Hsp70 immunoreactivity in smooth muscle cells of veins and did not increase the percentage of Hsp70-positive myofibers; however, sustained exposure to hypoxia affected the distribution of Hsp70 immunoreactivity, which appeared detectable in a very small subset of type 2A fibers, whereas it concentrated in type 1 myofibers (P < 0.05) together with the labeling for heme-oxygenase isoform 1, a marker of oxidative stress. Therefore, the chronic induction of Hsp70 expression in rat skeletal muscles is not obligatory related to the slow fiber phenotype but reveals the occurrence of a stress response. (literal)

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