http://www.cnr.it/ontology/cnr/individuo/prodotto/ID38348

Depressive symptoms, vascular risk factors and mild cognitive impairment. The Italian longitudinal study on aging. (Articolo in rivista)

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Depressive symptoms, vascular risk factors and mild cognitive impairment. The Italian longitudinal study on aging. (Articolo in rivista) (literal)

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Francesco Panza (a); Alessia D'Introno (a); Anna M. Colacicco (a); Cristiano Capurso (c); Angelo Del Parigi (h); Richard J. Caselli (j); Orlando Todarello (b); Vincenza Pellicani (b); Andrea Santamato (d); Pierluigi Scapicchio (e); Stefania Maggi (g); Emanuele Scafato (f); Claudia Gandin (f); Antonio Capurso (a); Vincenzo Solfrizzi (a); for the Italian Longitudinal Study on Aging Working Group (2008)
Depressive symptoms, vascular risk factors and mild cognitive impairment. The Italian longitudinal study on aging.
in Dementia and geriatric cognitive disorders
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Francesco Panza (a); Alessia D'Introno (a); Anna M. Colacicco (a); Cristiano Capurso (c); Angelo Del Parigi (h); Richard J. Caselli (j); Orlando Todarello (b); Vincenza Pellicani (b); Andrea Santamato (d); Pierluigi Scapicchio (e); Stefania Maggi (g); Emanuele Scafato (f); Claudia Gandin (f); Antonio Capurso (a); Vincenzo Solfrizzi (a); for the Italian Longitudinal Study on Aging Working Group (literal)

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a) Department of Geriatrics, Center for Aging Brain, Memory Unit b) Department of Neurological and Psychiatric Sciences, University of Bari, Bari , Departments of c) Geriatrics and d) Physical Medicine and Rehabilitation, University of Foggia, Foggia e) Catholic University of the Sacred Heart f) National Center for Epidemiology, Surveillance and Health Promotion - CNESPS, Istituto Superiore di Sanità, Rome g) National Research Council of Italy, CNR, Center on Aging, Padua , Italy h) National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Ariz. i) Department of Neurology, Mayo Clinic, Scottsdale, Ariz. , USA (literal)

Titolo

Depressive symptoms, vascular risk factors and mild cognitive impairment. The Italian longitudinal study on aging. (literal)

Abstract

Aims: We evaluated the impact of depressive symptoms on the rate of incident mild cognitive impairment (MCI) after a 3.5-year follow-up, and we assessed the interaction between depressive symptoms and vascular risk factors for incident MCI. Methods: A total of 2,963 individuals from a sample of 5,632 65-to 84-year-old subjects were cognitively and functionally evaluated at the 1st and 2nd surveys of the Italian Longitudinal Study on Aging, a prospective cohort study with a 3.5-year follow-up. MCI and dementia were classified using current clinical criteria. Depressive symptoms were measured with the Geriatric Depression Scale. Results: Among the 2,963 participants, 139 prevalent MCI cases were diagnosed at the 1st survey. During the 3.5-year follow-up, 105 new events of MCI were diagnosed. We did not observe any significant association between depressive symptoms and incident MCI (RR = 1.25, 95% CI = 0.85 -1.84, chi(2) = 1.30, p < 0.25). No sociodemographic variables or vascular risk factors modified the relationship between depressive symptoms and incident MCI. Conclusion: In our population, depressive symptoms were not associated with the rate of incident MCI. Our findings did not support a role of sociodemographic variables or vascular risk factors in the link between depressive symptoms and incident MCI. Copyright (C) 2008 S. Karger AG, Basel. (literal)

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