http://www.cnr.it/ontology/cnr/individuo/prodotto/ID38312

Pesticide exposure might be a strong risk factor for Parkinson's disease. (Articolo in rivista)

Type

Articolo in rivista (Classe)
Prodotto della ricerca (Classe)

Label

Pesticide exposure might be a strong risk factor for Parkinson's disease. (Articolo in rivista) (literal)

Anno

2008-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1002/ana.21049 (literal)

Alternative label

Baldereschi M, Inzitari M, Vanni P, Di Carlo A, Inzitari D. (2008)
Pesticide exposure might be a strong risk factor for Parkinson's disease.
in Annals of neurology
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Baldereschi M, Inzitari M, Vanni P, Di Carlo A, Inzitari D. (literal)

Pagina inizio

128 (literal)

Pagina fine

128 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

http://onlinelibrary.wiley.com/journal (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

63 (literal)

Rivista

Annals of neurology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

1 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

1 (literal)

Note

ISI Web of Science (WOS) (literal)
PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

Italian Natl Res Council, Inst Neurosci Italian Longitudinal Study Aging, Rome, Italy Azienda Osped Univ Careggi, Unit Gerontaol & Geriatrics, Dept Crit Care Med & Surg, Florence, Italy Univ Florence, Dept Neurol & Psychiat Sci, I-50121 Florence, Italy (literal)

Titolo

Pesticide exposure might be a strong risk factor for Parkinson's disease. (literal)

Abstract

We have read with great interest the recent article by Dr Ascherio and coworkers.1 From a large prospective investigation, their results strongly support the hypothesis that exposure to pesticides increases the risk for Parkinson's disease (PD). Given that farmers not exposed to pesticides were not at an increased risk for PD, the high proportion of farmers (76%) included in the study sample has indicated the direct effect of pesticides. However, the PD case-finding procedure has some major pitfalls: self-reported occurrence of PD is likely to lead to a considerable amount of underrecognized and underreported cases of the disease. In fact, the incidence rates that Ascherio and coworkers1 reported were somewhat lower than those previously reported in a population-based study with direct screening of each sampled individual and the clinical confirmation of those who screened positive.2 The authors are concerned about a possible selective underreporting of PD among the nonexposed individuals, with a consequent spurious positive association. On the other hand, in view of the strong and already reported association between pesticides and PD, we think the overlooked PD cases in the exposed population might outnumber those in the nonexposed population. Thus, the risk for PD might be underestimated. In fact, an ecological, population-based, crosssectional study could provide a higher risk ratio.3 We suggest that the results that Dr Ascherio and coworkers acquired through a self-reported mail questionnaire might not reflect accurately the magnitude of the risk or the amount of the disease that can be prevented. (literal)

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