The expression of PHOX2A, PHOX2B and of their target gene dopamine-beta-hydroxylase (DbetaH) is not modified by exposure to extremely-low-frequency electromagnetic field (ELF-EMF) in a human neuronal model. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• The expression of PHOX2A, PHOX2B and of their target gene dopamine-beta-hydroxylase (DbetaH) is not modified by exposure to extremely-low-frequency electromagnetic field (ELF-EMF) in a human neuronal model. (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.tiv.2008.05.003 (literal)

Alternative label

• Roberta Benfante, Ruth Adele Antonini; Niels Kuster; Juergen Schuderer; Christian Maercker; Franz Adlkofer;Francesco Clementi; Diego Fornasari (2008)
  The expression of PHOX2A, PHOX2B and of their target gene dopamine-beta-hydroxylase (DbetaH) is not modified by exposure to extremely-low-frequency electromagnetic field (ELF-EMF) in a human neuronal model.
  in Toxicology in vitro
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Roberta Benfante, Ruth Adele Antonini; Niels Kuster; Juergen Schuderer; Christian Maercker; Franz Adlkofer;Francesco Clementi; Diego Fornasari (literal)

Pagina inizio

• 1489 (literal)

Pagina fine

• 1495 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 22 (literal)

Rivista

• Toxicology in vitro (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 6 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• CNR, Istituto di Neuroscienze, Milano - Università degli Studi di Milano, Dip. di Farmacologia, Chemioterapia e Tossicologia Medica, Milano; CNR, Istituto di Neuroscienze, Milano - Università degli Studi di Milano, Dip. di Farmacologia, Chemioterapia e Tossicologia Medica, Milano; Swiss Fed Inst Technol ETH, Inst Integrated Syst, CH-8004 Zurich, Switzerland - Swiss Fed Inst Technol ETH, Fdn Res Informat Technol Soc ITIS, CH-8004 Zurich, Switzerland; Swiss Fed Inst Technol ETH, Inst Integrated Syst, CH-8004 Zurich, Switzerland - Swiss Fed Inst Technol ETH, Fdn Res Informat Technol Soc ITIS, CH-8004 Zurich, Switzerland; Univ Appl Sci, Dept Biotechnol, D-68163 Mannheim, Germany; VERUM Fdn, D-80336 Munich, Germany; CNR, Istituto di Neuroscienze, Milano - Università degli Studi di Milano, Dip. di Farmacologia, Chemioterapia e Tossicologia Medica, Milano; Università degli Studi di Milano, Dip. di Farmacologia, Chemioterapia e Tossicologia Medica, Milano - CNR, Istituto di Neuroscienze, Milano (literal)

Titolo

• The expression of PHOX2A, PHOX2B and of their target gene dopamine-beta-hydroxylase (DbetaH) is not modified by exposure to extremely-low-frequency electromagnetic field (ELF-EMF) in a human neuronal model. (literal)

Abstract

• The homeodomain transcription factors PHOX2A and PHOX2B are vital for development of the autonomic nervous system. Their spatial and temporal expression at the neural crest is instrumental in determining neuronal precursor fate, and by regulating DOH expression, the enzyme catalysing noradrenaline synthesis from dopamine, they also play a role in determination of noradrenergic phenotype. Disturbing this finely regulated process leads to disruption of autonomic development and autonomic dysfunction syndromes such as D beta H deficiency. As it had previously been shown that the catecholamine system is responsive to ELF-EMF, and as this has also been linked to various pathologies and to certain types of cancer, we wondered whether exposure to this type of radiation could affect the expression of PHOX2A, PHOX2B and D beta H, also during differentiation triggered by retinoic acid. To investigate this possibility we exposed the human SH-SY5Y neuroblastoma cell line to 50 Hz power-line magnetic field at various flux densities and for various exposure times. We measured gene expression in exposed cells compared to control cells and also investigated any changes at protein level. Using our exposure protocol, we found no changes at either transcript or protein level of these important components of the autonomic nervous system and catecholaminergic system. (literal)

Prodotto di

• Istituto di neuroscienze (IN) (Istituto)
• Modulazione recettoriale del differenziamento cellulare (ME.P03.004.001) (Modulo)

Autore CNR

• ROBERTA BENFANTE (Unità di personale esterno)
• RUTH ADELE ANTONINI (Persona)
• DIEGO MARIA MICHELE FORNASARI (Persona)
• FRANCESCO CLEMENTI (Unità di personale esterno)

Insieme di parole chiave

• Keywords of "The expression of PHOX2A, PHOX2B and of their target gene dopamine-beta-hydroxylase (DbetaH) is not modified by exposure to extremely-low-frequency electromagnetic field (ELF-EMF) in a human neuronal model." (Insieme di parole chiave)

Incoming links:

Autore CNR di

• FRANCESCO CLEMENTI (Unità di personale esterno)
• RUTH ADELE ANTONINI (Persona)
• DIEGO MARIA MICHELE FORNASARI (Persona)
• ROBERTA BENFANTE (Unità di personale esterno)

Prodotto

• Istituto di neuroscienze (IN) (Istituto)
• Modulazione recettoriale del differenziamento cellulare (ME.P03.004.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Toxicology in vitro (Rivista)

Insieme di parole chiave di

• Keywords of "The expression of PHOX2A, PHOX2B and of their target gene dopamine-beta-hydroxylase (DbetaH) is not modified by exposure to extremely-low-frequency electromagnetic field (ELF-EMF) in a human neuronal model." (Insieme di parole chiave)