Repeated exposure to alcoholic beer does not induce long-lasting changes in alcohol self-administration and intake in Sardinian alcohol-preferring (sP) and -non preferring (sNP) rats (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Repeated exposure to alcoholic beer does not induce long-lasting changes in alcohol self-administration and intake in Sardinian alcohol-preferring (sP) and -non preferring (sNP) rats (Articolo in rivista) (literal)

Anno

• 2007-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1093/alcalc/agm067 (literal)

Alternative label

• Orrù A., Lobina C., Maccioni P., Gessa G.L., Carai M.A.M., Colombo G (2007)
  Repeated exposure to alcoholic beer does not induce long-lasting changes in alcohol self-administration and intake in Sardinian alcohol-preferring (sP) and -non preferring (sNP) rats
  in Alcohol and alcoholism (Oxford)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Orrù A., Lobina C., Maccioni P., Gessa G.L., Carai M.A.M., Colombo G (literal)

Pagina inizio

• 513 (literal)

Pagina fine

• 524 (literal)

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• 42 (literal)

Rivista

• Alcohol and alcoholism (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 12 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 6 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• \"Bernard B. Brodie\" Department of Neuroscience, University of Cagliari, Italy; C.N.R. Institute of Neuroscience, Cagliari (CA), Italy (literal)

Titolo

• Repeated exposure to alcoholic beer does not induce long-lasting changes in alcohol self-administration and intake in Sardinian alcohol-preferring (sP) and -non preferring (sNP) rats (literal)

Abstract

• Background and Aims: Rats avidly consume nonalcoholic beer, and addition of alcohol to nonalcoholic beer may function as a medium to induce intake of large amounts of alcohol in rats. The present study investigated whether Sardinian alcohol-preferring (sP) and -non preferring (sNP) rats, initially exposed to nonalcoholic beer and subsequently to nonalcoholic beer containing increasing concentrations of alcohol, would develop unusually high alcohol self-administration and drinking behaviors (a) when alcohol was added to nonalcoholic beer and (b) once beer was removed and a plain alcohol solution was made available. Methods: In Experiment 1, rats were exposed to operant, 30-min/day self-administration sessions of nonalcoholic beer with increasing concentrations of alcohol [0%, 2.5%, 5%, 7.5%, and 10% (v/v)] for a total of 45 days. After a brief \"beer-fading\" phase, rats were exposed to self-administration sessions of a plain 10% (v/v) alcohol solution. In Experiment 2, rats were exposed to nonalcoholic beer with increasing concentrations of alcohol [0%, 2.5%, 5%, 7.5%, and 10% (v/v)] and water under the 2-bottle choice regimen with unlimited access (24 hours/day) for a total of 35 days. After a brief \"beer-fading\" phase, rats were exposed to the choice between a plain 10% (v/v) alcohol solution and water. Results: sP and sNP rats did not differ in self-administration (Experiment 1) and intake (Experiment 2) of nonalcoholic beer. In Experiment 1, as alcohol content increased, the amount of self-administered alcohol increased progressively in sP rats (up to 1-1.2 g/kg) and remained stable in sNP rats (approximately 0.65 g/kg). When the plain 10% alcohol solution was available, the amount of self-administered alcohol in sP rats initially dropped, and tended to increase - up to approximately 0.6 g/kg - on continuing exposure. In sNP rats, lever-pressing behavior rapidly estinguished after beer removal. In Experiment 2, as alcohol content increased, daily alcohol intake increased progressively in sP rats (up to 8-9 g/kg) and averaged approximately 2.4 g/kg in sNP rats. When the plain alcohol solution was available, daily alcohol intake in sP rats was initially low, reaching control values on continuing exposure; conversely, daily alcohol intake was completely suppressed in sNP rats. Conclusions: These results suggest that exposure to alcoholic beer resulted in unusually high intakes of alcohol in both sP and sNP rats for as long as nonalcoholic beer was added to alcohol; however, these high levels of alcohol self-administration and intake were not maintained once nonalcoholic beer was removed. (literal)

Prodotto di

• Neurobiologia dell'alcolismo (ME.P02.020.001) (Modulo)
• Istituto di neuroscienze (IN) (Istituto)

Autore CNR

• PAOLA MACCIONI (Unità di personale esterno)
• MAURO ANTONIO MARIA CARAI (Unità di personale esterno)
• CARLA LOBINA (Unità di personale esterno)
• GIANCARLO COLOMBO (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "Repeated exposure to alcoholic beer does not induce long-lasting changes in alcohol self-administration and intake in Sardinian alcohol-preferring (sP) and -non preferring (sNP) rats" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• GIANCARLO COLOMBO (Unità di personale interno)
• MAURO ANTONIO MARIA CARAI (Unità di personale esterno)
• PAOLA MACCIONI (Unità di personale esterno)
• CARLA LOBINA (Unità di personale esterno)

Prodotto

• Istituto di neuroscienze (IN) (Istituto)
• Neurobiologia dell'alcolismo (ME.P02.020.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Alcohol and alcoholism (Rivista)

Insieme di parole chiave di

• Parole chiave di "Repeated exposure to alcoholic beer does not induce long-lasting changes in alcohol self-administration and intake in Sardinian alcohol-preferring (sP) and -non preferring (sNP) rats" (Insieme di parole chiave)